Evidence map›Paper›PMID 23547048›Full record

ArticleThe Journal of clinical endocrinology and metabolism2013

Mineral metabolism and cortical volumetric bone mineral density in childhood chronic kidney disease.

Michelle R Denburg, Anne K Tsampalieros, Ian H de Boer, Justine Shults, Heidi J Kalkwarf, Babette S Zemel, Debbie Foerster, David Stokes, Mary B Leonard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
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  17. Treatment of hyperphosphatemia: the dangers of high PTH levels.Pediatric nephrology (Berlin, Germany) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Michelle R DenburgThe Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. denburgm@email.chop.edu
Anne K Tsampalieros
Ian H de Boer
Justine Shults
Heidi J Kalkwarf
Babette S Zemel
Debbie Foerster
David Stokes
Mary B Leonard
Children's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USUniversity of Ottawa · CAUniversity of Washington · US

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
STRUCTURAL EFFECTS OF RENAL OSTEODYSTROPHY DURING GROWTHR01HD040714 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI LEONARD, MARY BETH · 2002 to 2006
$2.6M
GLUCOCORTICOID-INDUCED OSTEOPENIA IN CHILDRENR01DK060030 · NIDDK · CHILDRENS HOSPITAL OF PHILADELPHIA · PI LEONARD, MARY BETH · 2001 to 2005
$1.8M
Patient Oriented Research in Vitamin D Deficiency in CKDK24DK076808 · NIDDK · STANFORD UNIVERSITY · PI LEONARD, MARY BETH · 2007 to 2016
$1.7M
Vitamin D Deficiency in Glomerular DiseaseK23DK093556 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI DENBURG, MICHELLE · 2012 to 2016
$858k
NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1TR000003NCATS NIH HHS UL1 TR000077NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1RR024134NICHD NIH HHS R01 HD040714NICHD NIH HHS R01-HD040714NIDDK NIH HHS K23 DK093556NIDDK NIH HHS K23DK093556NIDDK NIH HHS K24 DK076808NIDDK NIH HHS K24-DK076808NIDDK NIH HHS R01 DK060030NIDDK NIH HHS R01-DK060030
6 · The paper itself

Abstract

contextThe relationships among cortical volumetric bone mineral density (CortBMD) and comprehensive measures of mineral metabolism have not been addressed in chronic kidney disease (CKD).

objectiveThe aim of the study was to identify the determinants of CortBMD in childhood CKD. A secondary objective was to assess whether CortBMD was associated with subsequent fracture. DESIGN AND

participantsThis prospective cohort study included 171 children, adolescents, and young adults (aged 5-21 years) with CKD stages 2-5D at enrollment and 89 1 year later. OUTCOMES: Serum measures included vitamin D [25-hydroxyvitamin D (25[OH]D), 1,25-dihydroxyvitamin D (1,25(OH)₂D), 24,25-dihydroxyvitamin D], vitamin D-binding protein, intact PTH, fibroblast growth factor 23, calcium, and phosphorus. Tibia quantitative computed tomography measures of CortBMD were expressed as sex-, race-, and age-specific Z-scores based on 675 controls. Multivariable linear regression identified the independent correlates of CortBMD Z-scores and the change in CortBMD Z-scores.

resultsLower calcium (β = .31/1 mg/dL, P = .01) and 25(OH)D (β = .18/10 ng/mL, P = .04) and higher PTH (β = -.02/10%, P = .002) and 1,25(OH)₂D (β = -.07/10%, P < .001) were independently associated with lower CortBMD Z-scores at baseline. The correlations of total, free, and bioavailable 25(OH)D with CortBMD did not differ. Higher baseline 1,25(OH)₂D (P < .05) and greater increases in PTH (P < .001) were associated with greater declines in CortBMD Z-scores. Greater increases in calcium concentrations were associated with greater increases in CortBMD Z-scores in growing children (interaction P = .009). The hazard ratio for fracture was 1.75 (95% confidence interval 1.15-2.67; P = .009) per SD lower baseline CortBMD.

conclusionsGreater PTH and 1,25(OH)₂D and lower calcium concentrations were independently associated with baseline and progressive cortical deficits in childhood CKD. Lower CortBMD Z-score was associated with increased fracture risk.

Indexed as

Adolescent DevelopmentBone DevelopmentChild DevelopmentAdolescentAdultBone and BonesBone DensityBone ResorptionCalcitriolChildChild, PreschoolCohort StudiesErgocalciferolsFractures, BoneHumansHypocalcemia1,25-dihydroxyergocalciferolCalcitriolErgocalciferolsParathyroid HormonePTH protein, human

Identifiers

PMID23547048
PMCPMC3644604
OpenAlexW1982619140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.