ReviewClinical reviews in allergy & immunology2013
Diagnosis and management of immediate hypersensitivity reactions to cephalosporins.
Review in Clinical reviews in allergy & immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Ceftriaxone-Induced Pancytopenia: A Case Report.Hematology reports · 2025Article
- Engineering nanoallergens to investigate origins of immunogenicity and cross-reactivity in cephalosporin allergy.The Journal of allergy and clinical immunology · 2025Article
- Potential Factors of Primary Hospital Healthcare Professionals in Hindering the Abolition of Routine Skin Test for Cephalosporin: A Cross-Sectional Study.Risk management and healthcare policy · 2023Article
- Haematological and hepatic adverse effects of ceftriaxone in ambulatory care: a dual-centre retrospective observational analysis of standard vs high dose.BMC infectious diseases · 2022Observational
- Development and Validation for Quantification of Cephapirin and Ceftiofur by Ultraperformance Liquid Chromatography with Triple Quadrupole Mass Spectrometry.Molecules (Basel, Switzerland) · 2022Article
- Beta-lactam allergy labeling in intensive care units: An observational, retrospective study.Medicine · 2021Observational
- Cephalosporins' Cross-Reactivity and the High Degree of Required Knowledge. Case Report and Review of the Literature.Antibiotics (Basel, Switzerland) · 2020Article
- 'Cephalosporin allergy' label is misleading.Australian prescriber · 2018Review
- Bioanalytical development and validation of liquid chromatographic-tandem mass spectrometric methods for the quantification of total and free cefazolin in human plasma and cord blood.Practical laboratory medicine · 2015Article
- Immunologic evaluation of immediate hypersensitivity to cefaclor.Yonsei medical journal · 2014Article
- Diagnosis and management of immediate hypersensitivity reactions to cephalosporins.Allergy, asthma & immunology research · 2014Review
- Unique topics and issues in rheumatology and clinical immunology.Clinical reviews in allergy & immunology · 2014Article
- Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity.Computational and structural biotechnology journal · 2014Article
- Less travelled roads in clinical immunology and allergy: drug reactions and the environmental influence.Clinical reviews in allergy & immunology · 2013Review
- Cephalosporin Allergy: Current Understanding and Future Challenges.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cephalosporins are one of the most commonly prescribed classes of antibiotics. Immediate IgE-mediated hypersensitivity reactions have been reported with use of a specific cephalosporin, as a cross-reaction between different cephalosporins or as a cross-reaction to other β-lactam antibiotics, namely, penicillin. Historically, frequent reports of anaphylaxis following administration of first- and second-generation cephalosporins to patients with a history of penicillin allergy led to the belief of a high degree of allergic cross-reactivity. More recent evidence reveals a significantly lower risk of cross-reactivity between penicillins and the newer-generation cephalosporins. The current thought is that a shared side chain, rather than the β-lactam ring structure, is the determining factor in immunologic cross-reactivity. Understanding the chemical structure of these agents has allowed us to identify the allergenic determinants for penicillin; however, the exact allergenic determinants of cephalosporins are less well understood. For this reason, standardized diagnostic skin testing is not available for cephalosporins as it is for penicillin. Nevertheless, skin testing to the cephalosporin in question, using a nonirritating concentration, provides additional information, which can further guide the work-up of a patient suspected of having an allergy to that drug. Together, the history and the skin test results can assist the allergist in the decision to recommend continued drug avoidance or to perform a graded challenge versus an induction of tolerance procedure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.