ArticleClinical reviews in allergy & immunology2014
Rheumatoid arthritis bone fragility is associated with upregulation of IL17 and DKK1 gene expression.
Article in Clinical reviews in allergy & immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 36 citations in OpenAlex.
- Inflammatory cytokines mediate the common genetic and immunological background between rheumatoid arthritis and osteoporosis.Clinical rheumatology · 2026Article
- Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice.Journal of molecular medicine (Berlin, Germany) · 2022Article
- Mechanisms of Systemic Osteoporosis in Rheumatoid Arthritis.International journal of molecular sciences · 2022Review
- Atherosclerosis and Bone Loss in Humans-Results From Deceased Donors and From Patients Submitted to Carotid Endarterectomy.Frontiers in medicine · 2021Article
- Mango ginger (curcuma amada) inhibits collagen-induced arthritis by modulating inflammatory cytokine levels in ratsTurkish journal of medical sciences · 2020Article
- Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs.Scientific reports · 2020Article
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- Ankylosing Spondylitis Patients Have Impaired Osteoclast Gene Expression in Circulating Osteoclast Precursors.Frontiers in medicine · 2017Article
- Effect of Tumor Necrosis Factor Inhibitor Therapy on Osteoclasts Precursors in Rheumatoid Arthritis.BioMed research international · 2017Article
- Article
- Secondary osteoporosis in collagen-induced arthritis rats.Journal of bone and mineral metabolism · 2016Article
- The Impact of Conventional and Biological Disease Modifying Antirheumatic Drugs on Bone Biology. Rheumatoid Arthritis as a Case Study.Clinical reviews in allergy & immunology · 2016Review
- CD24: from a Hematopoietic Differentiation Antigen to a Genetic Risk Factor for Multiple Autoimmune Diseases.Clinical reviews in allergy & immunology · 2016Review
- Autoimmunity in 2014.Clinical reviews in allergy & immunology · 2015Review
- Arthritis induces early bone high turnover, structural degradation and mechanical weakness.PloS one · 2015Article
- Effect of Tumor Necrosis Factor Inhibitor Therapy on Osteoclasts Precursors in Ankylosing Spondylitis.PloS one · 2015Article
- Association between rheumatoid arthritics and osteoporosis among Chinese men, a community based study.International journal of clinical and experimental medicine · 2015Article
- Unique topics and issues in rheumatology and clinical immunology.Clinical reviews in allergy & immunology · 2014Article
- Autoimmunity in 2013.Clinical reviews in allergy & immunology · 2014Review
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to compare bone gene expression in rheumatoid arthritis (RA) and primary osteoporosis (OP) patients. Secondary aims were to determine the association of gene expression of the Wnt/β-catenin signaling pathway with inflammatory cytokines in the bone microenvironment and to assess the serum levels of Wnt/β-catenin proteins in both groups. RA patients referred for hip replacement surgery were recruited. Primary OP patients were used as controls. Gene expression of Wnt pathway mediators, matrix proteins, and pro-inflammatory cytokines were analyzed in bone samples. Bone turnover markers, inflammatory cytokines, and Wnt mediators were measured in serum. Twenty-two patients were included: 10 with RA and 12 with primary OP. The expressions of Wnt10b (p = 0.034), its co-receptor LRP6 (p = 0.041), and its negative regulator DKK1 (p = 0.008) were upregulated in RA bone. IL17 gene expression in bone was upregulated in RA patients (p = 0.031) and correlated positively with Wnt10b (r = 0.810, p = 0.015), DKK2 (r = 0.800, p = 0.010), and RANKL/OPG ratio (r = 0.762, p = 0.028). DKK2 (p = 0.04) was significantly decreased in RA serum compared with primary OP. In conclusion, bone fragility in RA patients is induced by an unbalanced bone microenvironment and is associated with a specific gene expression pattern, namely, the upregulation of IL17 and DKK1, suggesting that the modulation of these two pathways might prevent RA systemic bone loss.
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