Evidence map›Paper›PMID 23546620›Full record

ReviewCurrent protocols in protein science2013

Overview of protein microarrays.

F X Reymond Sutandy, Jiang Qian, Chien-Sheng Chen, Heng Zhu

Abstract readReview
In one paragraph

Review in Current protocols in protein science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

F X Reymond SutandyGraduate Institute of Systems Biology and Bioinformatics, National Central University, Jhongli, Taiwan.
Jiang Qian
Chien-Sheng Chen
Heng Zhu

Funding

TCP5: ACTIVE SITE LABELING REAGENT FOR ACETYLTRANSFERASESU54RR020839 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BOEKE, JEF D · 2004 to 2011
$27.4M
Monospecific monoclonal antibodies against human transcription factorsU54HG006434 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH, ZHU, HENG · 2011 to 2015
$13.8M
Proteome Characterization Center: A Genoproteomics Pipeline for Cance ResearchU24CA160036 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHAN, DANIEL WANYUI, ZHANG, HUI · 2011 to 2016
$10.7M
Lesch-Nyhan Disease: A Model for Complex Genetic, Proteomic & Metabolic PathwaysR24DK082840 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FRIEDMANN, THEODORE · 2008 to 2012
$7.3M
Networks, Pathways and Dynamics of Lysine ModificationU54GM103520 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BADER, JOEL S. · 2012 to 2013
$7.0M
Visual Programming Tool for Integrated Gene/Protein Networks in Cancer ResearchR44CA125807 · NCI · INCOGEN, INC. · PI SASINOWSKI, MACIEK · 2008 to 2011
$3.4M
DNA-Binding Activity of Human Transcription FactorsR01GM076102 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ZHU, HENG · 2006 to 2014
$2.6M
Computational Analysis of Retinal Regulatory Interactions: structure and dynamicsR01EY017589 · NEI · JOHNS HOPKINS UNIVERSITY · PI QIAN, JIANG · 2007 to 2010
$1.1M
Structural Protein Networks ("Interactome") in HerpesvirusesR21AI070740 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ZHU, HENG · 2006 to 2007
$443k
Visual Programming Tool for Integration of Gene and Protein Cancer Profiling DataR43CA125807 · NCI · INCOGEN, INC. · PI SASINOWSKI, MACIEK · 2007 to 2007
$150k
NCI NIH HHS CA125807NCI NIH HHS CA160036NCRR NIH HHS RR020839NCRR NIH HHS U54 RR020839NEI NIH HHS R01EY017589NHGRI NIH HHS HG006434NIAID NIH HHS R21 AI070740NIDDK NIH HHS DK082840NIGMS NIH HHS R01 GM076102NIGMS NIH HHS R01GM076102NIGMS NIH HHS U54 GM103520
6 · The paper itself

Abstract

Protein microarray technology is an emerging field that provides a versatile platform for the characterization of hundreds of thousands of proteins in a highly parallel and high-throughput manner. Protein microarrays are composed of two major classes: analytical and functional. In addition, tissue or cell lysates can also be fractionated and spotted on a slide to form a reverse-phase protein microarray. Applications of protein microarrays, especially functional protein microarrays, have flourished over the past decade as the fabrication technology has matured. In this unit, advances in protein microarray technologies are reviewed, and then a series of examples are presented to illustrate the applications of analytical and functional protein microarrays in both basic and clinical research. Relevant areas of research include the detection of various binding properties of proteins, the study of protein post-translational modifications, the analysis of host-microbe interactions, profiling antibody specificity, and the identification of biomarkers in autoimmune diseases.

Indexed as

AnimalsBiomarkersHumansProtein Array AnalysisProtein Processing, Post-TranslationalProteinsBiomarkersProteins

Identifiers

PMID23546620
PMCPMC3680110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.