Evidence map›Paper›PMID 23545572›Full record

ReviewCold Spring Harbor perspectives in medicine2013

Mechanisms of Francisella tularensis intracellular pathogenesis.

Jean Celli, Thomas C Zahrt

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 144 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. FEMS microbes · 2026
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  9. Host-pathogen interactions involved in erythrocyte invasion byFrontiers in cellular and infection microbiology · 2025
    Article
  10. Identification of theFrontiers in cellular and infection microbiology · 2025
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  11. Article
  12. Microorganisms · 2024
    Article
  13. Tick-Borne Bacterial Diseases in Europe: Threats to public health.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Review
  14. Breaking the cellular defense: the role of autophagy evasion inFrontiers in cellular and infection microbiology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Cells · 2023
    Article
  19. Glycerol monolaurate inhibitsmicroPublication biology · 2023
    Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jean CelliLaboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MO 59840, USA.
Thomas C Zahrt
Medical College of Wisconsin · US

Funding

Vaccines and Therapies Against BotulismU54AI057153 · NIAID · UNIVERSITY OF CHICAGO · PI SHUMAN, HOWARD A · 2003 to 2013
$87.6M
Molecular Basis of Francisella tularensis-Macrophage InteractionsZIAAI000953 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CELLI, JEAN · 2009 to 2013
$5.0M
Francisella - ATII interactions in respiratory tularemiaR21AI097597 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI ZAHRT, THOMAS C. · 2012 to 2013
$403k
Intramural NIH HHSNIAID NIH HHS 1R21 AI097597-01A1NIAID NIH HHS 2-U54-AI-057153NIAID NIH HHS R21 AI097597NIAID NIH HHS U54 AI057153
6 · The paper itself

Abstract

Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic and generally localized, the low infectious dose, with the ability to be transmitted to humans via multiple routes and the potential to cause life-threatening infections, has led to concerns that this bacterium could be used as an agent of bioterror and released intentionally into the environment. Recent studies of F. tularensis and other closely related Francisella species have greatly increased our understanding of mechanisms used by this organism to infect and cause disease within the host. Here, we review the intracellular life cycle of Francisella and highlight key genetic determinants and/or pathways that contribute to the survival and proliferation of this bacterium within host cells.

Indexed as

AnimalsCytosolFrancisella tularensisHumansImmunity, InnateInflammasomesLife Cycle StagesNADPH OxidasesPhagosomesReactive Oxygen SpeciesTularemiaZoonosesInflammasomesNADPH OxidasesReactive Oxygen Species

Identifiers

PMID23545572
PMCPMC3683997
OpenAlexW2141515959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.