Evidence map›Paper›PMID 23545571›Full record

ReviewCold Spring Harbor perspectives in medicine2013

Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era.

Maria Kostakioti, Maria Hadjifrangiskou, Scott J Hultgren

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 383 papers.

0numbers the graph read from it
0cells of the map it votes in
383citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

383 citing papers in PubMed, 972 citations in OpenAlex.

  1. The redefined identity ofJournal of bacteriology · 2026
    Review
  2. Article
  3. Review
  4. Whole-proteome structure/function prediction in UropathogenicbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
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  7. Article
  8. Article
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  11. Article
  12. Review
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  19. Article
  20. Review

323 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Maria KostakiotiDepartment of Molecular Microbiology and Microbial Pathogenesis, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110-1010, USA.
Maria Hadjifrangiskou
Scott J Hultgren
Washington University in St. Louis · USVanderbilt University · US

Funding

Virology and Smallpox VaccinationsU54AI057160 · NIAID · WASHINGTON UNIVERSITY · PI RAY, RANJIT · 2003 to 2013
$80.9M
pan-Genome of E.coli in the bladder and gut of women with recurrent UTIP50DK064540 · NIDDK · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2002 to 2017
$17.9M
YOGA LIFESTYLE INTERVENTION REDUCES BLOOD PRESSURE IN HIV-INFECTED ADULTSP41RR000954 · NCRR · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 1985 to 2011
$16.0M
MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
PATHOGENIC FIBER FORMATION IN BACTERIA: STRUCTURAL BASISR01AI048689 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2001 to 2020
$7.6M
CHAPERONE-ASSISTED PILI ASSEMBLY IN PATHOGENIC E. COLIR01AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J., YUAN, PENG · 1991 to 2023
$5.7M
Structure of Proteins Involved in Bacterial PathogenesisR01AI049950 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2001 to 2011
$3.4M
CHAPERONE ASSISTED PILI ASSEMBLY IN PATHOGENIC E COLIR37AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 1999 to 2008
$3.2M
Pathogenic Fiber Formation in Bacteria: Structural BasisR37AI048689 · NIAID · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 2021 to 2026
$2.9M
BIOGENESIS AND INHIBITION OF BIOFILM-ASSOCIATED BACTERIAL AMYLOIDR01AI099099 · NIAID · WASHINGTON UNIVERSITY · PI FRIEDEN, CARL, HULTGREN, SCOTT J. · 2013 to 2017
$1.9M
EFFECT OF CRANBERRY CONSTITUENTS ON UTI PATHOGENESISR01AT002058 · NCCIH · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J · 2004 to 2007
$1.4M
RATIONAL DESIGN OF MANNOSIDES FOR INHIBITION OF FIMH AND TREATMENT OF UTIRC1DK086378 · NIDDK · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2009 to 2010
$905k
NCCIH NIH HHS R01 AT002058NCRR NIH HHS P41 RR000954NIAID NIH HHS R01 AI029549NIAID NIH HHS R01 AI048689NIAID NIH HHS R01 AI049950NIAID NIH HHS R01 AI099099NIAID NIH HHS R37 AI029549NIAID NIH HHS R37 AI048689NIAID NIH HHS U54 AI057160NIDDK NIH HHS P50 DK064540NIDDK NIH HHS R01 DK051406NIDDK NIH HHS RC1 DK086378
6 · The paper itself

Abstract

Biofilm formation constitutes an alternative lifestyle in which microorganisms adopt a multicellular behavior that facilitates and/or prolongs survival in diverse environmental niches. Biofilms form on biotic and abiotic surfaces both in the environment and in the healthcare setting. In hospital wards, the formation of biofilms on vents and medical equipment enables pathogens to persist as reservoirs that can readily spread to patients. Inside the host, biofilms allow pathogens to subvert innate immune defenses and are thus associated with long-term persistence. Here we provide a general review of the steps leading to biofilm formation on surfaces and within eukaryotic cells, highlighting several medically important pathogens, and discuss recent advances on novel strategies aimed at biofilm prevention and/or dissolution.

Indexed as

Bacterial Physiological PhenomenaAmidohydrolasesAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacteriaBacterial AdhesionBiofilmsChelating AgentsEnzyme InhibitorsEquipment ContaminationExtracellular MatrixHumansPolysaccharides, BacterialSignal TransductionSilver CompoundsSpermidineAmidohydrolasesAnti-Bacterial AgentsAntimicrobial Cationic PeptidesChelating AgentsEnzyme InhibitorsnorspermidinePolysaccharides, BacterialSilver CompoundsSpermidine

Identifiers

PMID23545571
PMCPMC3683961
OpenAlexW2129723345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.