ArticleArchives of oral biology2013
Effects of Fam83h overexpression on enamel and dentine formation.
Article in Archives of oral biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Multiomics Data Synthesis of FAM83H in Amelogenesis Imperfecta.International dental journal · 2026Pooled it
- Expression ofInternational journal of molecular sciences · 2025Article
- Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models.Journal of visualized experiments : JoVE · 2024Article
- Tooth ultrastructure changes induced by a nonsense mutation in the FAM83H gene: insights into the diversity of amelogenesis imperfecta.Clinical oral investigations · 2023Article
- Identification of Prognostic Biomarkers Among FAM83 Family Genes in Human Ovarian Cancer Through Bioinformatic Analysis and Experimental Verification.Cancer management and research · 2021Article
- Decreased osteogenic activity and mineralization of alveolar bone cells from a patient with amelogenesis imperfecta andGenes & diseases · 2019Article
- Immunohistochemical Localization of Fam83h During Fluorosis-induced Mouse Molar Development.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Novel FAM83H mutations in patients with amelogenesis imperfecta.Scientific reports · 2017Article
- Amelogenesis Imperfecta; Genes, Proteins, and Pathways.Frontiers in physiology · 2017Review
- Evolutionary analysis of FAM83H in vertebrates.PloS one · 2017Article
- Fam83h null mice support a neomorphic mechanism for human ADHCAI.Molecular genetics & genomic medicine · 2016Article
- Missense Mutation in Fam83H Gene in Iranian Patients with Amelogenesis Imperfecta.Iranian journal of public health · 2014Article
- Ameloblast transcriptome changes from secretory to maturation stages.Connective tissue research · 2014Article
- Analysis of enamel development using murine model systems: approaches and limitations.Frontiers in physiology · 2014Review
- LAMB3 mutations causing autosomal-dominant amelogenesis imperfecta.Journal of dental research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThe aim of this study was to determine if FAM83H over-expression causes dentine or enamel malformations. MATERIALS AND
methodsThe full-length mouse Fam83h cDNA was inserted into the pCAGIG vector between a β-actin promoter and β-globin enhancer for ubiquitous expression in transgenic mice. Recombinant mouse FAM83H was expressed and used to generate polyclonal antibodies. Western blots showed enhanced expression of the Fam83h transgene. The effects of transgene expression on tooth development were assessed by microhardness measurements of enamel and dentine. Total thickness of incisor enamel at the level of the alveolar crest was measured and decussating rod patterns were visualized by scanning electron microscopy (SEM).
resultsThree transgenic mouse lines were selected based upon their transgene expression levels. There was no statistically significant difference in the Vickers microhardness values of enamel or dentine between the transgenic lines or between the transgenic lines and wild type mice. No statistically significant differences in enamel thickness were observed between the transgenic lines and the wild type mice. SEM analysis revealed no apparent differences in the enamel crystal and rod morphologies.
conclusionOur findings demonstrate that over-expression of FAM83H in mice does not produce a phenotype in dentine or enamel.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.