Evidence map›Paper›PMID 23545163›Full record

ArticleAmerican journal of obstetrics and gynecology2013

Progesterone blunts vascular endothelial cell secretion of endothelin-1 in response to placental ischemia.

Luissa V Kiprono, Kedra Wallace, Janae Moseley, James Martin, Babbette Lamarca

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of obstetrics and gynecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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  7. Progesterone-induced blocking factor blockade causes hypertension in pregnant rats.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Luissa V KipronoDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS. Electronic address: lkiprono@umc.edu.
Kedra Wallace
Janae Moseley
James Martin
Babbette Lamarca
University of Mississippi Medical Center · US

Funding

Mechanisms of Pregnancy Induced HypertensionF32HL078147 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI LAMARCA, BABBETTE · 2005 to 2007
$149k
NHLBI NIH HHS F32 HL078147
6 · The paper itself

Abstract

objectivePreeclampsia (PE) is associated with hypertension and elevated endothelin (ET-1), an indicator of endothelial cell activation and dysfunction. Reduction of uteroplacental perfusion (RUPP) in the pregnant rat model of PE is characterized by elevated mean arterial pressure, inflammatory cytokines, and activation of the ET-1 system. We aim to determine whether 17-alpha-hydroxyprogesterone caproate (17-OHPC) or progesterone suppresses these pathways. STUDY

designPlasma progesterone was purified from normal pregnant (NP) and PE patients and measured via enzyme-linked immunosorbent assay. Human umbilical vein endothelial cells were exposed to the sera with or without progesterone added and ET-1 was measured. Pregnant rats underwent the RUPP procedure with or without intraperitoneal 17-OHPC. Mean arterial pressure was compared in RUPP vs NP rats. Human umbilical vein endothelial cells were exposed to NP or RUPP sera, with and without progesterone and ET-1 measured.

resultsProgesterone was significantly decreased in PE women compared with NP women. In response to human sera, ET-1 was elevated in PE women compared to NP women, and decreased with addition of progesterone. Mean arterial pressure was significantly elevated in RUPP vs NP rats but was attenuated by 17-OHPC. ET-1 secretion was stimulated significantly by RUPP compared to NP rat sera, but attenuated by progesterone.

conclusionCirculating progesterone is significantly lower in PE women compared to controls. 17-OHPC attenuates hypertension in response to placental ischemia in RUPP rats. Progesterone blunts vascular ET-1 stimulated at cellular level by sera from PE women or RUPP rats. Decreased circulating progesterone is associated with stimulation of ET-1. 17-OHPC supplementation blunts hypertension and progesterone blunts endothelial cell ET-1 secretion in response to placental ischemia.

Indexed as

17 alpha-Hydroxyprogesterone CaproateAnimalsDisease Models, AnimalEndothelial CellsEndothelin-1Enzyme-Linked Immunosorbent AssayFemaleHumansHydroxyprogesteronesHypertensionIschemiaPlacentaPlacental CirculationPre-EclampsiaPregnancyProgesterone17 alpha-Hydroxyprogesterone CaproateEndothelin-1HydroxyprogesteronesProgesteroneProgestinsendothelinplacental ischemiapreeclampsiaprogesterone

Identifiers

PMID23545163
PMCPMC4052216
OpenAlexW2116256476

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.