Evidence map›Paper›PMID 23544406›Full record

ReviewNeurosurgical focus2013

Imaging preictal hemodynamic changes in neocortical epilepsy.

Kunal S Patel, Mingrui Zhao, Hongtao Ma, Theodore H Schwartz

Open access · bronzeAbstract readReview
In one paragraph

Review in Neurosurgical focus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Neural stimulation systems for the control of refractory epilepsy: a review.Journal of neuroengineering and rehabilitation · 2019
    Review
  6. Seizure prediction - ready for a new era.Nature reviews. Neurology · 2018
    Review
  7. Review
  8. Neuroimaging of epilepsy.Handbook of clinical neurology · 2016
    Review
  9. Future of seizure prediction and intervention: closing the loop.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kunal S PatelDepartment of Neurological Surgery, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10065, USA.
Mingrui Zhao
Hongtao Ma
Theodore H Schwartz
NewYork–Presbyterian Hospital · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6M
Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
Optical imaging of epilepsy in rat and human neocortexR01NS049482 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, THEODORE H · 2004 to 2007
$1.5M
NCATS NIH HHS UL1 TR000457NCRR NIH HHS UL1 RR 024996NCRR NIH HHS UL1 RR024996NINDS NIH HHS R01 NS049482NINDS NIH HHS R01NS49482
6 · The paper itself

Abstract

objectThe ability to predict seizure occurrence is extremely important to trigger abortive therapies and to warn patients and their caregivers. Optical imaging of hemodynamic parameters such as blood flow, blood volume, and tissue and hemoglobin oxygenation has already been shown to successfully localize epileptic events with high spatial and temporal resolution. The ability to actually predict seizure occurrence using hemodynamic parameters is less well explored.

methodsIn this article, the authors critically review data from the literature on neocortical epilepsy and optical imaging, and they discuss the preictal hemodynamic changes and their application in neurosurgery.

resultsRecent optical mapping studies have demonstrated preictal hemodynamic changes in both human and animal neocortex.

conclusionsOptical measurements of blood flow and oxygenation may become increasingly important for predicting and localizing epileptic events. The ability to successfully predict ictal onsets may be useful to trigger closed-loop abortive therapies.

Indexed as

ElectroencephalographyEpilepsyFunctional NeuroimagingHemodynamicsHumansNeocortex

Identifiers

PMID23544406
PMCPMC3961761
OpenAlexW2087082309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.