ArticlePloS one2013
Genomic analysis by deep sequencing of the probiotic Lactobacillus brevis KB290 harboring nine plasmids reveals genomic stability.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Modular biosynthesis of microbiome-derived polyketides and nonribosomal peptides: insights and opportunities for Lactobacillaceae.Microbial cell factories · 2026Review
- Characterization of Recombinant GH 43 β-Xylosidases and a GH 3 β-Glucosidase fromJournal of microbiology and biotechnology · 2026Article
- Safety Assessment of GABA-Producing Levilactobacillus brevis LAB6 MTCC 25662 and Its Anti-inflammatory Effects in Murine Macrophages.Probiotics and antimicrobial proteins · 2026Article
- Whole genome sequencing of promising Lactobacillus delbrueckii subsp. bulgaricus strains isolated from Egyptian dairy products for probiotic characteristics.Scientific reports · 2025Article
- Genomic Insights into ProbioticMicroorganisms · 2025Article
- Complete genome sequencing and probiotic characterization of promising lactic acid bacterial strains isolated from dairy products in Egyptian markets.BMC microbiology · 2025Article
- The Genome ofGenes · 2024Article
- Genome-based assessment of safety characteristics ofBioscience of microbiota, food and health · 2024Article
- Insights from metagenome-assembled genomes on the genetic stability and safety of over-the-counter probiotic products.Current genetics · 2023Article
- Metallobiology of Lactobacillaceae in the gut microbiome.Journal of inorganic biochemistry · 2023Review
- Identification of Type II Toxin-Antitoxin Loci in Levilactobacillus brevis.Interdisciplinary sciences, computational life sciences · 2022Article
- Lactobacillus brevis CD2: Fermentation Strategies and Extracellular Metabolites Characterization.Probiotics and antimicrobial proteins · 2020Article
- Comparative genome analysis ofMicrobial genomics · 2019Article
- Genome Sequence of Lactobacillus plantarum KB1253, a Gamma-Aminobutyric Acid (GABA) Producer Used in GABA-Enriched Tomato Juice Production.Microbiology resource announcements · 2019Article
- Genomic insights into a robust gamma-aminobutyric acid-producer Lactobacillus brevis CD0817.AMB Express · 2019Article
- Comparative genome analysis of the Lactobacillus brevis species.BMC genomics · 2019Article
- Biodiversity and Classification of Phages InfectingFrontiers in microbiology · 2019Article
- A Controlled FermentedFrontiers in pharmacology · 2018Article
- The Genomic Basis of Lactobacilli as Health-Promoting Organisms.Microbiology spectrum · 2017Review
- Complete Genome Sequence ofGenome announcements · 2017Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We determined the complete genome sequence of Lactobacillus brevis KB290, a probiotic lactic acid bacterium isolated from a traditional Japanese fermented vegetable. The genome contained a 2,395,134-bp chromosome that housed 2,391 protein-coding genes and nine plasmids that together accounted for 191 protein-coding genes. KB290 contained no virulence factor genes, and several genes related to presumptive cell wall-associated polysaccharide biosynthesis and the stress response were present in L. brevis KB290 but not in the closely related L. brevis ATCC 367. Plasmid-curing experiments revealed that the presence of plasmid pKB290-1 was essential for the strain's gastrointestinal tract tolerance and tendency to aggregate. Using next-generation deep sequencing of current and 18-year-old stock strains to detect low frequency variants, we evaluated genome stability. Deep sequencing of four periodic KB290 culture stocks with more than 1,000-fold coverage revealed 3 mutation sites and 37 minority variation sites, indicating long-term stability and providing a useful method for assessing the stability of industrial bacteria at the nucleotide level.
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