ArticlePloS one2013
Depressive symptoms in Crohn's disease: relationship with immune activation and tryptophan availability.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn's disease.World journal of gastroenterology · 2015Pooled it
- Psychological Comorbidities in Palmoplantar Psoriasis and Psoriatic Arthritis: A Systematic Review.Journal of cutaneous medicine and surgeryPooled it
- Depression and anxiety in inflammatory bowel disease: mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis.Frontiers in immunology · 2025Review
- Depressive symptoms and all-cause mortality among middle-aged and older people in China and associations with chronic diseases.Frontiers in public health · 2024Article
- TNF-α Mediates the Association between Dietary Inflammatory Index and Depressive Symptoms in Breast Cancer.Nutrients · 2022Article
- Validity and reliability of a checklist for patients with Behçet's disease based on the International Classification of Functioning, Disability and Health.Rheumatology international · 2022Article
- Measuring Mood and Anxiety Disorders by Patient Reported Outcomes in Inflammatory Bowel Disease: A Literature Review Update.Reviews on recent clinical trials · 2022Review
- The Association between Temperament, Chronotype, Depressive Symptoms, and Disease Activity among Patients with Inflammatory Bowel Disease-A Cross-Sectional Pilot Study.Life (Basel, Switzerland) · 2021Article
- Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.Journal of neuroinflammation · 2021Review
- Post-approval Safety Surveillance Study of Golimumab in the Treatment of Rheumatic Disease Using a United States Healthcare Claims Database.Clinical drug investigation · 2020Observational
- Impaired cognitive function in Crohn's disease: Relationship to disease activity.Brain, behavior, & immunity - health · 2020Article
- Exploring the Potential Antidepressant Mechanisms of TNFα Antagonists.Frontiers in neuroscience · 2019Review
- Vedolizumab Therapy Is Associated with an Improvement in Sleep Quality and Mood in Inflammatory Bowel Diseases.Digestive diseases and sciences · 2017Observational
- Effects of Mastalgia in Young Women on Quality of Life, Depression, and Anxiety Levels.The Indian journal of surgery · 2016Article
- Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression.Gastroenterology research and practice · 2016Article
- Treatment with immunosuppressive therapy may improve depressive symptoms in patients with inflammatory bowel disease.Digestive diseases and sciences · 2015Article
- The Involvement of TNF-α in Cognitive Dysfunction Associated with Major Depressive Disorder: An Opportunity for Domain Specific Treatments.Current neuropharmacology · 2015Review
- The role of Klebsiella in Crohn's disease with a potential for the use of antimicrobial measures.International journal of rheumatology · 2013Review
- Therapeutic efficacy of an elemental diet for patients with crohn's disease and its association with amino acid metabolism.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crohn's disease (CD) is associated with immune activation and depressive symptoms. This study determines the impact of anti-tumor necrosis factor (TNF)-α treatment in CD patients on depressive symptoms and the degree to which tryptophan (TRP) availability and immune markers mediate this effect. Fifteen patients with CD, eligible for anti-TNF-α treatment were recruited. Disease activity (Harvey-Bradshaw Index (HBI), Crohn's Disease Activity Index (CDAI)), fatigue (Multidimensional Fatigue Inventory (MFI)), quality of life (Inflammatory Bowel Disease Questionnaire (IBDQ)), symptoms of depression and anxiety (Symptom Checklist (SCL-90), Beck Depression Inventory (BDI), Hamilton Depression Rating Scale (HDRS)), immune activation (acute phase proteins (APP)), zinc and TRP availability were assessed before treatment and after 2, 4 and 8 weeks. Anti-TNF-α increased IBDQ scores and reduced all depression scores; however only SCL-90 depression scores remained decreased after correction for HBI. Positive APPs decreased, while negative APPs increased after treatment. After correction for HBI, both level and percentage of γ fraction were associated with SCL-90 depression scores over time. After correction for HBI, patients with current/past depressive disorder displayed higher levels of positive APPs and lower levels of negative APPs and zinc. TRP availability remained invariant over time and there was no association between SCL-90 depression scores and TRP availability. Inflammatory reactions in CD are more evident in patients with comorbid depression, regardless of disease activity. Anti-TNF-α treatment in CD reduces depressive symptoms, in part independently of disease activity; there was no evidence that this effect was mediated by immune-induced changes in TRP availability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.