ArticlePloS one2013
Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Genomic Insights Into the Evolution of Parental Care in Weevils.Genome biology and evolution · 2026Article
- Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration.The EMBO journal · 2024Article
- Wengen's hidden powers: ROS triggers a TNFR-dependent tissue regenerative pathway in Drosophila.The EMBO journal · 2024Article
- A novel method for identifying key genes in macroevolution based on deep learning with attention mechanism.Scientific reports · 2023Article
- Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila.Nature communications · 2023Article
- The TNFR Wengen regulates the FGF pathway by an unconventional mechanism.Nature communications · 2023Article
- Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.Nature communications · 2021Article
- The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila.Molecular brain · 2017Article
- Eiger-induced cell death relies on Rac1-dependent endocytosis.Cell death & disease · 2016Article
- Control of axon-axon attraction by Semaphorin reverse signaling.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Photoreceptor neurons (R cells) in the Drosophila eye define a map of visual space by connecting to targets in distinct layers of the optic lobe, with R1-6 cells connecting to the lamina (the first optic ganglion) and R7 and R8 cells connecting to the medulla (the second optic ganglion). Here, we show that Wengen (Wgn) directly binds Moesin (Moe) through a cytosolic membrane proximal domain and this interaction is important for mediating two distinct aspects of axonal targeting. First, we show that loss of wgn or moe function disrupts cell autonomous R8 axon targeting. Second, we report that wgn or moe mutants show defects in R2-R5 targeting that result from disruption of non-cell autonomous effects, which are secondary to the cell autonomous R8 phenotype. Thus, these studies reveal that the Wgn-Moe signaling cascade plays a key role in photoreceptor target field innervations through cell autonomous and non-cell autonomous mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.