ArticlePloS one2013
Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Identification of central regulators related to residual feed intake in Huainan chickens based on weighted gene co-expression network analysis.Poultry science · 2026Article
- Low Testosterone and High Leptin Activate PPAR Signaling to Induce Adipogenesis and Promote Fat Deposition in Caponized Ganders.International journal of molecular sciences · 2024Article
- Effects of Caponization on Growth Performance and Carcass Composition of Yangzhou Ganders.Animals : an open access journal from MDPI · 2022Article
- The transcriptome pattern of liver, spleen and hypothalamus provides insights into genetic and biological changes in roosters in response to castration.Frontiers in genetics · 2022Article
- Nocturnal One-Hour Lighting Stimulates Gonadal Development and Lowers Fat Deposition in Male Mule Ducks.Animals : an open access journal from MDPI · 2021Article
- The Influence of Sex on the Slaughter Parameters and Selected Blood Indices of Greenleg Partridge, Polish Native Breed of Hens.Animals : an open access journal from MDPI · 2021Article
- Effect of Vitamin E Supplementation on Deposition and Gene Expression Profiling of Abdominal Fat in Broiler Chickens.The journal of poultry science · 2021Article
- Transcriptome landscapes of differentially expressed genes related to fat deposits in Nandan-Yao chicken.Functional & integrative genomics · 2021Article
- Transcriptome Analysis Identifies Candidate Genes and Signaling Pathways Associated With Feed Efficiency in Xiayan Chicken.Frontiers in genetics · 2021Article
- Ovary removal modifies liver message RNA profiles in single Comb White Leghorn chickens.Poultry science · 2020Article
- Effects of aging and menopause on pancreatic fat fraction in healthy women population: A strobe-compliant article.Medicine · 2019Article
- The serum level of a novel lipogenic protein Spot 14 was reduced in metabolic syndrome.PloS one · 2019Article
- Decreased testosterone levels after caponization leads to abdominal fat deposition in chickens.BMC genomics · 2018Article
- Performance differences of Rhode Island Red, Bashang Long-tail Chicken, and their reciprocal crossbreds under natural cold stress.Asian-Australasian journal of animal sciences · 2017Article
- Investigating right ovary degeneration in chick embryos by transcriptome sequencing.The Journal of reproduction and development · 2017Article
- Combination analysis of genome-wide association and transcriptome sequencing of residual feed intake in quality chickens.BMC genomics · 2016Article
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- Comparative analysis of temporal gene expression patterns in the developing ovary of the embryonic chicken.The Journal of reproduction and development · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capons are male chickens whose testes have been surgically incised. Capons show a significant increase in fat accumulation compared to intact male chickens. However, while caponization leads to a significant reduction in androgen levels in roosters, little is known about the molecular mechanisms through which androgen status affects lipogenesis in avian species. Therefore, investigation of the influence of androgens on fat accumulation in the chicken will provide insights into this process. In this study, Affymetrix microarray technology was used to analyze the gene expression profiles of livers from capons and intact male chickens because the liver is the major site of lipogenesis in avian species. Through gene ontology, we found that genes involved in hepatic lipogenic biosynthesis were the most highly enriched. Interestingly, among the upregulated genes, the cytosolic form of the phosphoenolpyruvate carboxykinase (PCK1) gene showed the greatest fold change. Additionally, in conjunction with quantitative real-time PCR data, our results suggested that androgen status negatively regulated the PCK1 gene in male chickens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.