Evidence map›Paper›PMID 23543848›Full record

ArticleAnatomy & physiology : current research2012

The Dynamics of Global Chromatin Remodeling are Pivotal for Tracking the Normal Pluripotency of Human Embryonic Stem Cells.

Xuejun H Parsons

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Anatomy & physiology : current research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Xuejun H ParsonsSan Diego Regenerative Medicine Institute, San Diego, CA 92109, USA ; Xcelthera, San Diego, CA 92109, USA.
Regenerative Medicine Institute · MX

Funding

Epigenetic Controls in hESC Dopaminergic FateK01AG024496 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PARSONS, XUEJUN H · 2005 to 2009
$610k
Mapping hESC neuronal lineage programmingR21HD056530 · NICHD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI PARSONS, XUEJUN H · 2009 to 2010
$415k
NIA NIH HHS K01 AG024496NICHD NIH HHS R21 HD056530
6 · The paper itself

Abstract

Pluripotent Human Embryonic Stem Cells (hESCs) have the unconstrained capacity for long-term stable undifferentiated growth in culture and unrestricted developmental capacity. Packaging of the eukaryotic genome into chromatin confers higher order structural control over maintaining stem cell plasticity and directing differentiation. We recently reported the establishment of a defined culture system for sustaining the epiblast pluripotence of hESCs, serving as a platform for

Indexed as

ChromatinChromatin remodelingDefined culture systemDifferentiationEpigeneticHistone acetylationHistone acetyltransferaseHistone deacetylaseHistone deacetylationHistone methylationHistone methytransferaseHistone modificationHuman embryonic stem cellsOct-4Pluripotency

Identifiers

PMID23543848
PMCPMC3609651
OpenAlexW113182238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.