ArticleThe Plant cell2013
Roles of N-terminal fatty acid acylations in membrane compartment partitioning: Arabidopsis h-type thioredoxins as a case study.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 79 citations in OpenAlex.
- Arabidopsis proteinProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Members of theInternational journal of molecular sciences · 2024Article
- Focus on Nitric Oxide Homeostasis: Direct and Indirect Enzymatic Regulation of Protein Denitrosation Reactions in Plants.Antioxidants (Basel, Switzerland) · 2022Review
- Demyristoylation of the Cytoplasmic Redox Protein Trx-h2 Is Critical for Inducing a Rapid Cold Stress Response in Plants.Antioxidants (Basel, Switzerland) · 2021Article
- Redox-dependent structural switch and CBF activation confer freezing tolerance in plants.Nature plants · 2021Article
- ThioredoxinAntioxidants (Basel, Switzerland) · 2021Article
- Protein Phosphorylation Response to Abiotic Stress in Plants.Methods in molecular biology (Clifton, N.J.) · 2021Review
- High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.Nature communications · 2020Article
- A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis.Nature plants · 2019Article
- On the role of the plant mitochondrial thioredoxin system during abiotic stress.Plant signaling & behavior · 2019Article
- Generation of Superoxide by OeRbohH, a NADPH Oxidase Activity During Olive (Frontiers in plant science · 2019Article
- Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern.Nature chemical biology · 2018Article
- Targeted Profiling ofThe Plant cell · 2018Article
- A Lipid-Anchored NAC Transcription Factor Is Translocated into the Nucleus and ActivatesThe Plant cell · 2017Article
- Mitochondrial AtTrxo1 is transcriptionally regulated by AtbZIP9 and AtAZF2 and affects seed germination under saline conditions.Journal of experimental botany · 2017Article
- A novel motif in the NaTrxh N-terminus promotes its secretion, whereas the C-terminus participates in its interaction with S-RNase in vitro.BMC plant biology · 2014Article
- The role of lipid post-translational modification in plant developmental processes.Frontiers in plant science · 2014Review
- Palmitoylation in plants: new insights through proteomics.Plant signaling & behavior · 2013Article
- Golgi traffic and integrity depend on N-myristoyl transferase-1 in Arabidopsis.The Plant cell · 2013Article
- Thiol-based redox regulation in sexual plant reproduction: new insights and perspectives.Frontiers in plant science · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-terminal fatty acylations (N-myristoylation [MYR] and S-palmitoylation [PAL]) are crucial modifications affecting 2 to 4% of eukaryotic proteins. The role of these modifications is to target proteins to membranes. Predictive tools have revealed unexpected targets of these acylations in Arabidopsis thaliana and other plants. However, little is known about how N-terminal lipidation governs membrane compartmentalization of proteins in plants. We show here that h-type thioredoxins (h-TRXs) cluster in four evolutionary subgroups displaying strictly conserved N-terminal modifications. It was predicted that one subgroup undergoes only MYR and another undergoes both MYR and PAL. We used plant TRXs as a model protein family to explore the effect of MYR alone or MYR and PAL in the same family of proteins. We used a high-throughput biochemical strategy to assess MYR of specific TRXs. Moreover, various TRX-green fluorescent protein fusions revealed that MYR localized protein to the endomembrane system and that partitioning between this membrane compartment and the cytosol correlated with the catalytic efficiency of the N-myristoyltransferase acting at the N terminus of the TRXs. Generalization of these results was obtained using several randomly selected Arabidopsis proteins displaying a MYR site only. Finally, we demonstrated that a palmitoylatable Cys residue flanking the MYR site is crucial to localize proteins to micropatching zones of the plasma membrane.
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