ArticleIndian journal of clinical biochemistry : IJCB2012
Neurochemical and neurobehavioral effects of low lead exposure on the developing brain.
Article in Indian journal of clinical biochemistry : IJCB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biomarkers and Tourette syndrome: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Neurocognitive consequences of occupational heavy metal exposure among electronic waste sorting workers in Thailand.Narra J · 2026Article
- Developmental Pb exposure increases rate of forgetting on a delayed matching-to-sample task among Mexican children.Science advances · 2025Article
- A Bio-Indicator Pilot Study Screening Selected Heavy Metals in Female Hair, Nails, and Serum from Lifestyle Cosmetic, Canned Food, and Manufactured Drink Choices.Molecules (Basel, Switzerland) · 2023Article
- Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders.Archives of Razi Institute · 2022Review
- Exposure of metal toxicity in Alzheimer's disease: An extensive review.Frontiers in pharmacology · 2022Review
- Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites.Molecules (Basel, Switzerland) · 2021Review
- Protective Effect of Vitamin D3 Against Pb-Induced Neurotoxicity by Regulating the Nrf2 and NF-κB Pathways.Neurotoxicity research · 2021Article
- Long-Term Lead Exposure Since Adolescence Causes Proteomic and Morphological Alterations in the Cerebellum Associated with Motor Deficits in Adult Rats.International journal of molecular sciences · 2020Article
- Blood Transcriptome Response to Environmental Metal Exposure Reveals Potential Biological Processes Related to Alzheimer's Disease.Frontiers in public health · 2020Article
- The Neuroprotective Role of Coenzyme Q10 Against Lead Acetate-Induced Neurotoxicity Is Mediated by Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities.International journal of environmental research and public health · 2019Article
- Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation.Journal of molecular biology · 2019Review
- Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity.Neurochemical research · 2016Review
- Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb).Neurotoxicology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead is found in small but appreciable quantities in air, soil drinking water and food. Exposure to such amounts of lead does not cause acute lead toxicity, but produces subtle effects, particularly in children. The CDC advocates "safe" or "acceptable" levels of blood lead up to 10 μg/dl, while OSHA declares blood lead levels up to 40 μg/dl as "safe" or "acceptable" in the occupationally exposed. The objective of the study was to see if blood levels considered "safe" can cause changes in the biogenic neurotransmitters in the developing brain which may cause neurobehavioral defects like hyperactivity and other cognitive disorders. Albino Wistar rats were divided into the control and lead-treated groups. The control group was given unleaded water, while the lead-treated group was fed with 50 ppm lead acetate in drinking water. On day 45 the animals were subjected to a passive avoidance test, their blood analysed for ZPP and lead. They were then sacrificed and the neurotransmitters-Norepinephrine (NE) and its metabolite-methoxyhydroxyphenylglycol (MHPG) estimated in the brain areas associated with learning and memory-the frontal cortex, hippocampus and the striatum by HPLC-ECD. Our results showed significant increases in blood lead, NE and MHPG, while ZPP increase was insignificant. The rats showed neurobehavioral abnormalities as assessed by the passive avoidance test. We concluded that low blood levels of lead cannot be considered "safe" or "acceptable" as it causes neurotransmitter alterations. Increased NE turnover is implicated in hyperactivity disorders such as ADHD and Tourette syndrome.
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