ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- The sympathetic nervous system enhances host immune responses to enteric bacterial pathogens in mice.Brain, behavior, and immunity · 2025Article
- The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection.Cell reports. Medicine · 2024Article
- The Sympathetic Nervous System Is Necessary for Development of CD4+ T-Cell Memory Following Staphylococcus aureus Infection.The Journal of infectious diseases · 2023Article
- [Role of the sympathetic nervous system in chronic inflammation].Zeitschrift fur Rheumatologie · 2023Review
- The α7 Nicotinic Acetylcholine Receptor Agonist GTS-21 Improves Bacterial ClearanceFrontiers in immunology · 2022Article
- Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord.Journal of neuroinflammation · 2020Article
- Nervous system control of intestinal host defense in C. elegans.Current opinion in neurobiology · 2020Review
- Effects of Cardiac Sympathetic Neurodegeneration and PPARBioMed research international · 2020Article
- Frontline Science: Rev-Erbα links blue light with enhanced bacterial clearance and improved survival in murine Klebsiella pneumoniae pneumonia.Journal of leukocyte biology · 2020Article
- Beneficial role of bioactive lipids in the pathobiology, prevention, and management of HBV, HCV and alcoholic hepatitis, NAFLD, and liver cirrhosis: A review.Journal of advanced research · 2019Review
- Octopaminergic Signaling Mediates Neural Regulation of Innate Immunity in Caenorhabditis elegans.mBio · 2018Article
- The interstitium in cardiac repair: role of the immune-stromal cell interplay.Nature reviews. Cardiology · 2018Review
- Splenic involvement in umbilical cord matrix-derived mesenchymal stromal cell-mediated effects following traumatic spinal cord injury.Journal of neuroinflammation · 2018Article
- An overview of the role of sympathetic regulation of immune responses in infectious disease and autoimmunity.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2018Review
- Hypothesis: Fever control, a niche for alpha-2 agonists in the setting of septic shock and severe acute respiratory distress syndrome?Temperature (Austin, Tex.) · 2018Review
- Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function.Critical care medicine · 2017Article
- Ly6Chigh Monocytes Protect against Kidney Damage during Sepsis via a CX3CR1-Dependent Adhesion Mechanism.Journal of the American Society of Nephrology : JASN · 2016Article
- The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease.Trends in immunology · 2015Review
- Article
- CRH promotes S. pneumoniae growth in vitro and increases lung carriage in mice.Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Effective host defense requires a robust, yet self-limited response to pathogens. A poorly calibrated response can lead to either bacterial dissemination due to insufficient inflammation or organ injury due to excessive inflammation. Recent evidence suggests that the cholinergic anti-inflammatory reflex helps calibrate the immune response. However, the influence of peripheral noradrenergic neurons, which are primarily sympathetic neurons, in regulating immunity remains incompletely characterized. Using a model of 6-hydroxydopamine-mediated noradrenergic nerve ablation, we show that elimination of noradrenergic neurons improves survival during Klebsiella pneumoniae peritonitis (67 versus 23%, p < 0.005) in mice. The survival benefit results from enhanced MCP-1-dependent monocyte recruitment and a subsequent decrease in bacterial loads. Splenectomy eliminated both the survival benefit of 6-hydroxydopamine and monocyte recruitment, suggesting that monocytes recruited to the peritoneum originate in the spleen. These results suggest that noradrenergic neurons regulate the immune response through two pathways. First, sympathetic nerve-derived norepinephrine directly restrains MCP-1 production by peritoneal macrophages during infection. Second, norepinephrine derived from the vagally innervated splenic nerve regulates splenic monocyte egress. Removal of these two modulators of the immune response enhances antibacterial immunity and improves survival. These results may have implications for how states of catecholamine excess influence the host response to bacterial infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.