ArticleFrontiers in neural circuits2013
Distinct spatiotemporal activity in principal neurons of the mouse olfactory bulb in anesthetized and awake states.
Article in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Design Principles From Natural Olfaction for Electronic Noses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- Anesthetized animal experiments for neuroscience research.Frontiers in neural circuits · 2024Review
- Stability and flexibility of odor representations in the mouse olfactory bulb.Frontiers in neural circuits · 2023Article
- Anesthesia inhibited corticospinal excitability and attenuated the modulation of repetitive transcranial magnetic stimulation.BMC anesthesiology · 2022Article
- Smell-induced gamma oscillations in human olfactory cortex are required for accurate perception of odor identity.PLoS biology · 2022Article
- Plasticity in olfactory bulb circuits.Current opinion in neurobiology · 2020Review
- Deciphering Brain Function by Miniaturized Fluorescence Microscopy in Freely Behaving Animals.Frontiers in neuroscience · 2020Review
- Primacy coding facilitates effective odor discrimination when receptor sensitivities are tuned.PLoS computational biology · 2019Article
- Sparsened neuronal activity in an optogenetically activated olfactory glomerulus.Scientific reports · 2018Article
- Article
- Learning-Dependent and -Independent Enhancement of Mitral/Tufted Cell Glomerular Odor Responses Following Olfactory Fear Conditioning in Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb.NeuroImage · 2018Article
- Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation.Nature communications · 2018Article
- Measuring the olfactory bulb input-output transformation reveals a contribution to the perception of odorant concentration invariance.Nature communications · 2017Article
- Article
- Behavioral Status Influences the Dependence of Odorant-Induced Change in Firing on Prestimulus Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Reading Out Olfactory Receptors: Feedforward Circuits Detect Odors in Mixtures without Demixing.Neuron · 2016Article
- Article
Corrections and comments
- Erratum issuedKnöpfel, Thomas [added]
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acquisition of olfactory information and its early processing in mammals are modulated by brain states through sniffing behavior and neural feedback. We imaged the spatiotemporal pattern of odor-evoked activity in a population of output neurons (mitral/tufted cells, MTCs) in the olfactory bulb (OB) of head-restrained mice expressing a genetically-encoded calcium indicator. The temporal dynamics of MTC population activity were relatively simple in anesthetized animals, but were highly variable in awake animals. However, the apparently irregular activity in awake animals could be predicted well using sniff timing measured externally, or inferred through fluctuations in the global responses of MTC population even without explicit knowledge of sniff times. The overall spatial pattern of activity was conserved across states, but odor responses had a diffuse spatial component in anesthetized mice that was less prominent during wakefulness. Multi-photon microscopy indicated that MTC lateral dendrites were the likely source of spatially disperse responses in the anesthetized animal. Our data demonstrate that the temporal and spatial dynamics of MTCs can be significantly modulated by behavioral state, and that the ensemble activity of MTCs can provide information about sniff timing to downstream circuits to help decode odor responses.
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