ArticlePaediatrics & child health2012
Iron's role in paediatric restless legs syndrome - a review.
Article in Paediatrics & child health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Does Improvement of Low Serum Ferritin Improve Symptoms of Restless Legs Syndrome in a Cohort of Pediatric Patients?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Trial
- Italian adaptation of international recommendations for the management of restless legs syndrome: A consensus statement by the scientific committee of RLS-Italia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Restless legs syndrome in children with celiac disease: associations with vitamin D and iron deficiency and the role of gluten-free diet adherence.BMC pediatrics · 2026Article
- Sensory feeding problems, pica-related behaviors, and sleep habits among children with autism spectrum disorder in palestine: a parent-reported cross-sectional study.Frontiers in pediatrics · 2026Article
- Restless Sleep Disorder in Children: An Educational Review on Diagnosis, Pathophysiology, and Management.Movement disorders clinical practice · 2025Review
- Review
- Iron Deficiency and Restless Sleep/Wake Behaviors in Neurodevelopmental Disorders and Mental Health Conditions.Nutrients · 2024Article
- Iron Deficiency among School-Aged Adolescents in Hong Kong: Prevalence, Predictors, and Effects on Health-Related Quality of Life.International journal of environmental research and public health · 2023Article
- Prevalence of growing pains in a general paediatric OPD: A descriptive, observational and cross-sectional study.Journal of family medicine and primary care · 2023Article
- Trends in ferritin measurements in children and adolescents: A Finnish 9-year observational study.Acta paediatrica (Oslo, Norway : 1992) · 2022Observational
- Tourette disorder and sleep.Biomedical journal · 2022Review
- Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation.Translational pediatrics · 2020Review
- Refractory Insomnia in an Adolescent with Total Blindness.The Yale journal of biology and medicine · 2019Article
- Effect of Oral Iron Administration on Mental State in Children With Low Serum Ferritin Concentration.Global pediatric health · 2019Article
- Excessive daytime sleepiness in adolescents: current treatment strategies.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paediatric restless legs syndrome (RLS) treatment is important because RLS's associated sleep disturbance causes significant developmental-behavioural morbidity and impacts family well-being. RLS is associated with brain iron insufficiency and dopaminergic dysfunction. Diagnosis requires fulfillment of diagnostic criteria, which for children are currently in evolution, and have limitations, especially in preschoolers. The community physician needs to recognize the possibility of RLS to refer to a sleep specialist for diagnostic confirmation and management recommendations, which include oral iron therapy, even though there is currently no definitive research evidence for iron efficacy in most children with RLS. A 3 mg to 6 mg elemental iron/kg/day dose for three months could be tried if the ferritin level is <50 ug/L. Sleep hygiene and behavioural strategies are also recommended. Iron supplementation should be safe in the absence of iron metabolism disorders, provided that transferrin saturation and ferritin levels are monitored pre-and post-treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.