ArticleGenetica2013
An extreme test of mutational meltdown shows mutational firm up instead.
Article in Genetica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditionally, the accumulation of new deleterious mutations in populations or species in low numbers is expected to lead to a reduction in fitness and mutational meltdown, but in this study the opposite was observed. Beginning with a highly inbred populations of Drosophila melanogaster, new mutations that accumulated in experiments of two females and two males or of one female and one male each generation for 52 generations did not cause a decline in progeny numbers over time. Only two lines went extinct among 52 tested lines. In three of four experiments there was a significant increase in progeny numbers over time (mutational firm up), which had to be due to new beneficial, compensatory, overdominant, or back mutations.
Indexed as
Identifiers
23543206What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.