ArticleMolecular genetics and genomics : MGG2013
Functional analysis of the carS gene of Fusarium fujikuroi.
Article in Molecular genetics and genomics : MGG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025Review
- The photoinduced β-carotene synthesis inFrontiers in microbiology · 2025Article
- HmbC, a Protein of the HMG Family, Participates in the Regulation of Carotenoid Biosynthesis inGenes · 2023Article
- Genetic and Environmental Factors Influencing the Production of Select Fungal Colorants: Challenges and Opportunities in Industrial Applications.Journal of fungi (Basel, Switzerland) · 2023Review
- Relation between CarS expression and activation of carotenogenesis by stress inFrontiers in bioengineering and biotechnology · 2022Article
- TheNon-coding RNA · 2021Article
- Controlled Transcription of Regulator GeneMicroorganisms · 2020Article
- Neurosporaxanthin Overproduction byAntioxidants (Basel, Switzerland) · 2020Article
- A Negative Regulator of Carotenogenesis inApplied and environmental microbiology · 2020Article
- A novel lncRNA as a positive regulator of carotenoid biosynthesis in Fusarium.Scientific reports · 2020Article
- Comparative transcriptomic analysis unveils interactions between the regulatory CarS protein and light response in Fusarium.BMC genomics · 2019Article
- Carotenoid Biosynthesis in Fusarium.Journal of fungi (Basel, Switzerland) · 2017Review
- Genome Sequencing of Multiple Isolates Highlights Subtelomeric Genomic Diversity within Fusarium fujikuroi.Genome biology and evolution · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ascomycete fungus Fusarium fujikuroi is a model system in the investigation of the biosynthesis of some secondary metabolites, such as gibberellins, bikaverin, and carotenoids. Carotenoid-overproducing mutants, generically called carS, are easily obtained in this fungus by standard mutagenesis procedures. Here we report the functional characterization of gene carS, responsible for this mutant phenotype. The identity of the gene was demonstrated through the finding of mutations in six independent carS mutants and by the complementation of one of them. The F. fujikuroi carS gene was able to restore the control of carotenogenesis in a similar deregulated mutant of Fusarium oxysporum, but only partially at the transcription level, indicating an unexpected complexity in the regulation of the pathway. Due to the pleiotropic characteristics of this mutation, which also modifies the production of other secondary metabolites, we did a screening for carS-regulated genes by subtracted cDNA hybridization. The results show that the carS mutation affects the regulation of numerous genes in addition to those of carotenogenesis. The expression of the identified genes was usually enhanced by light, a regulatory effect also exhibited by the carS gene. However, in most cases, their mRNA levels in carS mutants were similar to those of the wild type, suggesting a regulation that affects mRNA availability rather than mRNA synthesis.
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