ReviewInternational urology and nephrology2013
Loss of heparin-binding protein prevents necrotizing glomerulonephritis: first clues hint at plasminogen activator inhibitor-1.
Review in International urology and nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Elevated Midkine Serum Levels Are Associated with Long-Term Survival in Critically Ill Patients.International journal of molecular sciences · 2023Article
- Glomerular Endothelial Cells Are the Coordinator in the Development of Diabetic Nephropathy.Frontiers in medicine · 2021Article
- Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases.British journal of pharmacology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The orchestration of acute inflammatory kidney injury is subject to widespread influences and involves cytokines as well as chemokines released by resident as well as infiltrating cells. Although intense research efforts have been made in the field, it still unravels yet novel key molecules involved in the pathogenesis of this kidney disease. A heparin-binding growth factor denoted midkine is expressed by various cell types following stress of tissue damage. Specific functions relate to orchestration of reparative and inflammatory processes by promoting migration of leucocytes and release of chemokines with ensuing angiogenesis. Midkine appears as a double-edged sword with beneficial or harmful effects in injured tissues. Here, we discuss a recent publication that provides evidence for the beneficial role of midkine in progressive glomerulonephritis, most likely due to blockade of plasminogen activator inhibitor-1 release.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.