ArticleClinical and experimental nephrology2013
Replication study for the association of 3 SNP loci identified in a genome-wide association study for diabetic nephropathy in European type 1 diabetes with diabetic nephropathy in Japanese patients with type 2 diabetes.
Article in Clinical and experimental nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
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- IGF1 and PPARG polymorphisms are associated with reduced estimated glomerular filtration rate in a cohort of children and adolescents with type 1 diabetes.Acta diabetologica · 2023Article
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- Genetic variants ofFrontiers in endocrinology · 2023Article
- Diabetic kidney disease: Are the reported associations with single-nucleotide polymorphisms disease-specific?World journal of diabetes · 2021Article
- Multi-Omics Data Analysis Uncovers Molecular Networks and Gene Regulators for Metabolic Biomarkers.Biomolecules · 2021Article
- Leptin Receptor-DeficientFrontiers in nutrition · 2021Article
- Genetic and Epigenetic Studies in Diabetic Kidney Disease.Frontiers in genetics · 2019Review
- ErbB4 deletion predisposes to development of metabolic syndrome in mice.American journal of physiology. Endocrinology and metabolism · 2018Article
- ErbB4 deletion accelerates renal fibrosis following renal injury.American journal of physiology. Renal physiology · 2018Article
- Genetics of cardiovascular and renal complications in diabetes.Journal of diabetes investigation · 2016Review
- Genetics of diabetic nephropathy: a long road of discovery.Current diabetes reports · 2015Review
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Authors and funding
15 authors at 7 institutions in 1 country.
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Abstract
backgroundA recent genome-wide association study for diabetic nephropathy in European type 1 diabetes identified 3 candidate loci for diabetic nephropathy. In this study, we examined the association of the 3 single nucleotide polymorphism (SNP) loci with susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.
methodsWe genotyped 3 SNPs, rs7583877 in AFF3, rs12437854 in the RGMA-MCTP2 locus and rs7588550 in ERBB4, for 2,300 Japanese patients with type 2 diabetes [initial study, 1,055 nephropathy cases with overt proteinuria or with end-stage renal disease (ESRD) and 1,245 control patients with normoalbuminuria]. The association of these SNPs with diabetic nephropathy was examined by using a logistic regression analysis.
resultsWe observed a significant association of rs7588550 in ERBB4 with diabetic nephropathy in the Japanese patients with type 2 diabetes, although the effect direction was not consistent with that in the European study [p = 0.0126, odds ratio (OR) = 0.79, 95 % confidence interval (CI): 0.65-0.95]. We further examined the association of rs7588550 with diabetic nephropathy in an independent Japanese cohort (596 nephropathy cases and 311 controls) and observed the same trend of the association with the initial study. We did not observe any association of the remaining 2 SNP loci with diabetic nephropathy in the present Japanese sample.
conclusionThe association of SNP loci derived from GWAS in European type 1 diabetes with diabetic nephropathy was not replicated in the Japanese patients with type 2 diabetes, although the ERBB4 locus may have some effect also in Japanese type 2 diabetes.
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