ArticleFrontiers in microbiology2013
The diversity of anti-microbial secondary metabolites produced by fungal endophytes: an interdisciplinary perspective.
Article in Frontiers in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed, 318 citations in OpenAlex.
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- Endophytic Fungi Associated with Seaweeds as Potential Producers of Antimicrobial Compounds.Marine biotechnology (New York, N.Y.) · 2026Article
- Characterization of anticariogenic mycosymbiotic fungi associated with the medicinal plant Piper crocatum.Scientific reports · 2026Article
- Iterative enrichment cultivation and multiomic analysis reveal potential endophytic bacteria affecting the sinomenine synthesis in Sinomenium acutum.Microbial cell factories · 2026Article
- Volatilized Metabolites Produced by Soilborne Aspergillus flavus Regulate Fungal Conidiation, and Production of Secondary Metabolites.Journal of chemical ecology · 2026Article
- In-silico screening of marine fungal metabolites identifies potential FtsZ inhibitors against MDR-tuberculosis through docking and molecular dynamics analysis.Scientific reports · 2026Article
- Essential Oil ofPlants (Basel, Switzerland) · 2025Article
- Diversity and Biocontrol Potential of Fungi Associated with Cyst Nematodes and Soils in Swiss Potato Agroecosystems.Plants (Basel, Switzerland) · 2025Article
- Harnessing microbial consortia to induce systemic resistance and modulate gene expression in cluster bean under bacterial blight (Xanthomonas axonopodis pv. cyamopsidis) stress.World journal of microbiology & biotechnology · 2025Article
- Computational Evaluation of Fusarium nygamai Compounds as AcrD Efflux Pump Protein Inhibitors of Salmonella Typhimurium.Molecular biotechnology · 2025Article
- Anticancer Activity of Benzomalvin Derivatives Isolated fromJournal of microbiology and biotechnology · 2025Article
- Fungus-derived opine enhances plant photosynthesis.Journal of advanced research · 2025Article
- Decoding fungal communication networks: molecular signaling, genetic regulation, and ecological implications.Functional & integrative genomics · 2025Review
- Nematicidal and antifeedant activity of ethyl acetate extracts from culture filtrates of Arabidopsis thaliana fungal endophytes.Scientific reports · 2025Article
- Bioactive Metabolites of Serratia sp. NhPB1 Isolated from Pitcher of Nepenthes and its Application to Control Pythium aphanidermatum.Probiotics and antimicrobial proteins · 2025Article
- Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics.Journal of fungi (Basel, Switzerland) · 2025Review
- The Combination of Shading and Potassium Application Regulated the Bulb Active Ingredients Accumulation inMicroorganisms · 2025Article
- Carbon substrates utilization determine antagonistic fungal-fungal interactions among root-associated fungi.Frontiers in microbiology · 2025Article
- Endophytic Fungi ofJournal of fungi (Basel, Switzerland) · 2024Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endophytes are microbes that inhabit host plants without causing disease and are reported to be reservoirs of metabolites that combat microbes and other pathogens. Here we review diverse classes of secondary metabolites, focusing on anti-microbial compounds, synthesized by fungal endophytes including terpenoids, alkaloids, phenylpropanoids, aliphatic compounds, polyketides, and peptides from the interdisciplinary perspectives of biochemistry, genetics, fungal biology, host plant biology, human and plant pathology. Several trends were apparent. First, host plants are often investigated for endophytes when there is prior indigenous knowledge concerning human medicinal uses (e.g., Chinese herbs). However, within their native ecosystems, and where investigated, endophytes were shown to produce compounds that target pathogens of the host plant. In a few examples, both fungal endophytes and their hosts were reported to produce the same compounds. Terpenoids and polyketides are the most purified anti-microbial secondary metabolites from endophytes, while flavonoids and lignans are rare. Examples are provided where fungal genes encoding anti-microbial compounds are clustered on chromosomes. As different genera of fungi can produce the same metabolite, genetic clustering may facilitate sharing of anti-microbial secondary metabolites between fungi. We discuss gaps in the literature and how more interdisciplinary research may lead to new opportunities to develop bio-based commercial products to combat global crop and human pathogens.
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