Evidence map›Paper›PMID 23542923›Full record

SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2014

Practical issues for the use of tranexamic acid in total knee arthroplasty: a systematic review.

Tae Kyun Kim, Chong Bum Chang, In Jun Koh

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03690037 (Single Centre Randomised Controlled Trial to Assess the Effect of the Addition of Twenty-four Hours of Oral Tranexamic Acid Post-operatively to a Single Intra-operative Intravenous Dose of Tranexamic Acid on Calculated Blood Loss Following Primary Hip and Knee Arthroplasty.), which is not on this map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03690037 phase4completednot on this mapstarted 2016, after this paper: background citation

Single Centre Randomised Controlled Trial to Assess the Effect of the Addition of Twenty-four Hours of Oral Tranexamic Acid Post-operatively to a Single Intra-operative Intravenous Dose of Tranexamic Acid on Calculated Blood Loss Following Primary Hip and Knee Arthroplasty.

TypeinterventionalSponsorBelfast Health and Social Care TrustRan2016 to 2019Enrolled1,089ConditionsPrimary Total Knee Arthroplasty, Primary Total Hip ArthroplastyArmsTranexamic Acid 100 MG/ML, Tranexamic Acid 500 MG
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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  6. Efficacy and Safety of Tranexamic Acid in Bilateral Total Knee Replacement: A Meta-Analysis and Systematic Review.Medical science monitor : international medical journal of experimental and clinical research · 2015
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  10. Effect of different postoperative flexion regimes on the outcomes of total knee arthroplasty: randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Tae Kyun KimJoint Reconstruction Center, Seoul National University Bundang Hospital, 166 Gumiro, Bundanggu, Seongnamsi, Gyeonggi-do, 463-707, Republic of Korea, osktk@snubh.org.
Chong Bum Chang
In Jun Koh
Seoul National University Bundang Hospital · KRThe Catholic University of Korea Uijeongbu St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis systematic review was undertaken to answer three specific questions relating to the clinical values of tranexamic acid (TNA) in total knee arthroplasty (TKA): (1) Whether there are differences in blood-saving effects between the systemic and topical administrations; (2) Whether blood-saving effects of TNA differ by doses and timings of administration; and (3) Whether the use of TNA is safe at all reported doses, timings, and routes of administration with respect to the incidences of symptomatic deep-vein thrombosis (DVT) and pulmonary embolism (PE).

methodsA systematic review was carried out with 28 randomised controlled trials to evaluate the efficacy and safety of TNA use in TKA identified from the literature.

resultsBoth systemic and topical administrations reduced blood loss after TKA, but transfusion reducing effects varied in studies whether systemic or topical administrations. The effects of TNA were influenced by doses and timings of administration. No increased incidences of symptomatic DVT and PE were found for all reported doses, timings, and routes of TNA administration.

conclusionSurgeons can consider incorporating the use of TNA to their blood-saving protocols in TKA without serious concern of adverse events but need to adopt optimal doses, timings, and routes of TNA administrations.

Indexed as

Arthroplasty, Replacement, KneeAntifibrinolytic AgentsBlood Loss, SurgicalDose-Response Relationship, DrugDrug Administration RoutesDrug Administration ScheduleFemaleHumansIncidenceMaleMiddle AgedPulmonary EmbolismRandomized Controlled Trials as TopicTranexamic AcidTreatment OutcomeVenous ThrombosisAntifibrinolytic AgentsTranexamic Acid

Identifiers

PMID23542923
OpenAlexW2005960014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.