ArticleMolecular cell2013
The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans.
Article in Molecular cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 59 citations in OpenAlex.
- Target-Directed miRNA Degradation: Mechanisms and Significance.Methods in molecular biology (Clifton, N.J.) · 2026Article
- What goes up must come down: off switches for regulatory RNAs.Genes & development · 2024Review
- To kill a microRNA: emerging concepts in target-directed microRNA degradation.Nucleic acids research · 2024Review
- Recent advances in understanding microRNA function and regulation in C. elegans.Seminars in cell & developmental biology · 2024Review
- Characterisation of the in-vivo miRNA landscape in Drosophila ribonuclease mutants reveals Pacman-mediated regulation of the highly conserved let-7 cluster during apoptotic processes.Frontiers in genetics · 2024Article
- CSDE1 promotes miR-451 biogenesis.Nucleic acids research · 2023Article
- A Compilation of the Diverse miRNA Functions inInternational journal of molecular sciences · 2023Review
- The developmentally timed decay of an essential microRNA family is seed-sequence dependent.Cell reports · 2022Article
- mRNA-Decapping Associated DcpS Enzyme Controls Critical Steps of Neuronal Development.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans.Nucleic acids research · 2021Article
- PQN-59 antagonizes microRNA-mediated repression during post-embryonic temporal patterning and modulates translation and stress granule formation in C. elegans.PLoS genetics · 2021Article
- Effect of the His-Tag Location on Decapping Scavenger Enzymes and Their Hydrolytic Activity toward Cap Analogs.ACS omega · 2020Article
- AtXRN4 Affects the Turnover of Chosen miRNA*s inPlants (Basel, Switzerland) · 2020Article
- Recent Molecular Genetic Explorations ofGenetics · 2018Article
- The Interplay between the RNA Decay and Translation Machinery in Eukaryotes.Cold Spring Harbor perspectives in biology · 2018Review
- Target RNAs Strike Back on MicroRNAs.Frontiers in genetics · 2018Review
- Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA-guided gene silencingThe EMBO journal · 2017Article
- A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing.Nucleic acids research · 2017Article
- Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition.Nucleic acids research · 2017Article
- TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells.Nucleic acids research · 2017Article
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8 authors at 4 institutions in 3 countries.
Funding
Abstract
In metazoans, microRNAs play a critical role in the posttranscriptional regulation of genes required for cell proliferation and differentiation. MicroRNAs themselves are regulated by a multitude of mechanisms influencing their transcription and posttranscriptional maturation. However, there is only sparse knowledge on pathways regulating the mature, functional form of microRNA. Here, we uncover the implication of the decapping scavenger protein DCS-1 in the control of microRNA turnover. In Caenorhabditis elegans, mutations in dcs-1 increase the levels of functional microRNAs. We demonstrate that DCS-1 interacts with the exonuclease XRN-1 to promote microRNA degradation in an independent manner from its known decapping scavenger activity, establishing two molecular functions for DCS-1. Our findings thus indicate that DCS-1 is part of a degradation complex that performs microRNA turnover in animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.