ArticleCurrent biology : CB2013
A synthetic gene drive system for local, reversible modification and suppression of insect populations.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed.
- Advances in CRISPR gene drives for mosquito population control.Current opinion in microbiology · 2026Review
- Genetic Allee Effects for Controlling Invasive Populations.Molecular ecology · 2026Article
- Predicting the invasiveness of threshold-dependent gene drives.bioRxiv : the preprint server for biology · 2025Article
- Population genomics of Aedes albopictus across remote Pacific islands for genetic biocontrol considerations.PLoS neglected tropical diseases · 2025Article
- Performance of two low-threshold population replacement gene drives in cage populations of the yellow fever mosquito, Aedes aegypti.PLoS genetics · 2025Article
- A Comparative Assessment of Self-limiting Genetic Control Strategies for Population Suppression.Molecular biology and evolution · 2025Article
- Ecology of Gene Drives: The Role of Density-Dependent Feedbacks on the Efficacy and Dynamics of Two-Locus Underdominance Gene Drive Systems.Evolutionary applications · 2025Article
- Advancements and Future Prospects of CRISPR-Cas-Based Population Replacement Strategies in Insect Pest Management.Insects · 2024Review
- Modelling daisy quorum drive: A short-term bridge across engineered fitness valleys.PLoS genetics · 2024Article
- Predicting thresholds for population replacement gene drives.BMC biology · 2024Article
- A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations.Nature communications · 2024Article
- Manipulating the Destiny of Wild Populations Using CRISPR.Annual review of genetics · 2023Review
- Direct and indirect gene repression by the ecdysone cascade during mosquito reproductive cycle.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reflection on the Challenges, Accomplishments, and New Frontiers of Gene Drives.Biodesign research · 2022Review
- Driving down malaria transmission with engineered gene drives.Frontiers in genetics · 2022Review
- Demystifying the Risk Assessment Process for Laboratory-Based Experiments Utilizing Invasive Genetic Elements: It Is More Than Gene Drive.Applied biosafety : journal of the American Biological Safety Association · 2021Article
- A common gene drive language eases regulatory process and eco-evolutionary extensions.BMC ecology and evolution · 2021Article
- Combating mosquito-borne diseases using genetic control technologies.Nature communications · 2021Review
- Engineered reproductively isolated species drive reversible population replacement.Nature communications · 2021Article
- Design and analysis of CRISPR-based underdominance toxin-antidote gene drives.Evolutionary applications · 2021Article
21 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
Replacement of wild insect populations with genetically modified individuals unable to transmit disease provides a self-perpetuating method of disease prevention but requires a gene drive mechanism to spread these traits to high frequency. Drive mechanisms requiring that transgenes exceed a threshold frequency in order to spread are attractive because they bring about local but not global replacement, and transgenes can be eliminated through dilution of the population with wild-type individuals. These features are likely to be important in many social and regulatory contexts. Here we describe the first creation of a synthetic threshold-dependent gene drive system, designated maternal-effect lethal underdominance (UD(MEL)), in which two maternally expressed toxins, located on separate chromosomes, are each linked with a zygotic antidote able to rescue maternal-effect lethality of the other toxin. We demonstrate threshold-dependent replacement in single- and two-locus configurations in Drosophila. Models suggest that transgene spread can often be limited to local environments. They also show that in a population in which single-locus UD(MEL) has been carried out, repeated release of wild-type males can result in population suppression, a novel method of genetic population manipulation.
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