ArticleInsect biochemistry and molecular biology2013
The insulin/TOR signal transduction pathway is involved in the nutritional regulation of juvenile hormone synthesis in Aedes aegypti.
Article in Insect biochemistry and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 105 citations in OpenAlex.
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- Dietary L-3,4-dihydroxyphenylalanine (L-DOPA) augments cuticular melanization in Anopheles mosquitos reducing their lifespan and malaria burden.Nature communications · 2025Article
- Functions of Insulin-like Peptide Genes (Insects · 2024Article
- The Molecular Substrates of Insect Eusociality.Annual review of genetics · 2024Review
- Internal and external drivers interact to create highly dynamic mosquito blood-feeding behaviour.Proceedings. Biological sciences · 2024Review
- Transcriptomics Provide Insights into the Photoperiodic Regulation of Reproductive Diapause in the Green Lacewing,Insects · 2024Article
- Differential gene expression and microRNA profile in corpora allata-corpora cardiaca of Aedes aegypti mosquitoes with weak juvenile hormone signalling.BMC genomics · 2024Article
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- Insulin-like peptides and ovary ecdysteroidogenic hormone differentially stimulate physiological processes regulating egg formation in the mosquito Aedes aegypti.Insect biochemistry and molecular biology · 2023Article
- Crosstalk between Nutrition, Insulin, Juvenile Hormone, and Ecdysteroid Signaling in the Classical Insect Model,International journal of molecular sciences · 2022Article
- miR-275/305 cluster is essential for maintaining energy metabolic homeostasis by the insulin signaling pathway in Bactrocera dorsalis.PLoS genetics · 2022Article
- A chromosome-level genome assembly provides insights into the environmental adaptability and outbreaks of Chlorops oryzae.Communications biology · 2022Article
- Target of rapamycin (Journal of biosciences · 2021Article
- The Amino Acid-Mediated TOR Pathway Regulates Reproductive Potential and Population Growth inFrontiers in physiology · 2020Article
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- TOR as a Regulatory Target inFrontiers in physiology · 2019Article
- Omics approaches to study juvenile hormone synthesis.Current opinion in insect science · 2018Review
- MicroRNA Tissue Atlas of the Malaria MosquitoG3 (Bethesda, Md.) · 2018Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Juvenile hormone (JH) levels must be modulated to permit the normal progress of development and reproductive maturation in mosquitoes. JH is part of a transduction system that assesses nutritional information and controls reproduction in mosquitoes. Adult female Aedes aegypti show nutritionally-dependent dynamic changes in corpora allata (CA) JH biosynthetic activities. A coordinated expression of most JH biosynthetic enzymes has been described in female pupae and adult mosquitoes; increases or decreases in transcript levels for all the enzymes were concurrent with increases or decreases in JH synthesis; suggesting that transcriptional changes are at least partially responsible for the dynamic changes of JH biosynthesis. The goal of the present study is to identify signaling network components responsible for the nutritional-dependent changes of JH synthesis in the CA of mosquitoes. The insulin/TOR signaling network plays a central role in the transduction of nutritional signals that regulate cell growth and metabolism in insects. These pathways have also been suggested as a link between nutritional signals and JH synthesis regulation in the CA of cockroaches and flies. We used a combination of in vitro studies and in vivo genetic knockdown experiments to explore nutritional signaling pathways in the CA. Our results suggest that the insulin/TOR pathway plays a role in the transduction of the nutritional information that regulates JH synthesis in mosquitoes. Transcriptional regulation of the genes encoding JH biosynthetic enzymes is at least partially responsible for these nutritionally modulated changes of JH biosynthesis.
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