ArticleThe Journal of allergy and clinical immunology2013
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Newborn blood DNA methylation and childhood asthma: findings from the ECHO program.International journal of epidemiology · 2025Pooled it
- Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis.Environmental health perspectives · 2019Pooled it
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- The multifaceted role of FAM13A in pulmonary diseases.Frontiers in genetics · 2026Review
- Integrated Bioinformatics and Experimental Validation of Inflammatory Cytokine-Related Hub Genes in Pediatric Asthma.Journal of asthma and allergy · 2026Article
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- Genetic analyses of chr11p15.5 region identifyThe Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Genomics of Treatable Traits in Asthma.Genes · 2023Review
- Pulmonary comorbidities in psoriasis are associated with a high risk of respiratory failure.The Journal of international medical research · 2023Article
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- Comparison of tumor and two types of paratumoral tissues highlighted epigenetic regulation of transcription during field cancerization in non-small cell lung cancer.BMC medical genomics · 2022Article
- Airway Disease in Rheumatoid Arthritis.Annals of the American Thoracic Society · 2022Review
- Machine learning implicates the IL-18 signaling axis in severe asthma.JCI insight · 2021Article
- FUNCTION-ON-FUNCTION REGRESSION FOR THE IDENTIFICATION OF EPIGENETIC REGIONS EXHIBITING WINDOWS OF SUSCEPTIBILITY TO ENVIRONMENTAL EXPOSURES.The annals of applied statistics · 2021Article
- Sex-specific longitudinal association of DNA methylation with lung function.ERJ open research · 2021Article
- Nasal DNA methylation differentiates severe from non-severe asthma in African-American children.Allergy · 2021Article
- Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate-to-Severe Asthma.American journal of respiratory and critical care medicine · 2021Article
- Epigenome-wide association study on asthma and chronic obstructive pulmonary disease overlap reveals aberrant DNA methylations related to clinical phenotypes.Scientific reports · 2021Article
- Pre-adolescence DNA methylation is associated with lung function trajectories from pre-adolescence to adulthood.Clinical epigenetics · 2021Article
Corrections and comments
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Authors and funding
20 authors at 10 institutions in 1 country.
Funding
Abstract
backgroundRecent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function.
objectiveWe sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations.
methodsGenome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted forced vital capacity, and FEV1/forced vital capacity ratio) were performed in 4 white populations of European descent (n = 1544), followed by meta-analyses.
resultsSeven of 28 previously identified lung function loci (HHIP, FAM13A, THSD4, GSTCD, NOTCH4-AGER, RARB, and ZNF323) identified in general populations were confirmed at single nucleotide polymorphism (SNP) levels (P < .05). Four of 32 loci (IL12A, IL12RB1, STAT4, and IRF2) associated with ppFEV1 (P < 10(-4)) belong to the TH1 or IL-12 cytokine family pathway. By using a linear additive model, these 4 TH1 pathway SNPs cumulatively explained 2.9% to 7.8% of the variance in ppFEV1 values in 4 populations (P = 3 × 10(-11)). Genetic scores of these 4 SNPs were associated with ppFEV1 values (P = 2 × 10(-7)) and the American Thoracic Society severe asthma classification (P = .005) in the Severe Asthma Research Program population. TH2 pathway genes (IL13, TSLP, IL33, and IL1RL1) conferring asthma susceptibility were not associated with lung function.
conclusionGenes involved in airway structure/remodeling are associated with lung function in both general populations and asthmatic subjects. TH1 pathway genes involved in anti-virus/bacterial infection and inflammation modify lung function in asthmatic subjects. Genes associated with lung function that might affect asthma severity are distinct from those genes associated with asthma susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.