Evidence map›Paper›PMID 23541163›Full record

Trial reportThe Journal of clinical psychiatry2013

Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity.

Elizabeth A Hoge, Eric Bui, Luana Marques, Christina A Metcalf, Laura K Morris, Donald J Robinaugh, John J Worthington, Mark H Pollack, Naomi M Simon

4 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 176 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01033851 phase4completednot on this map

Stress Reduction Techniques and Anxiety: Therapeutic and Neuroendocrine Effects

TypeinterventionalSponsorMassachusetts General HospitalRan2008 to 2013Enrolled89ConditionsGeneralized Anxiety DisorderArmsMindfulness Based Stress Reduction, Stress Management Education
NCT04307563 nacompletednot on this mapstarted 2021, after this paper: background citation

Behavioral Health Support for Health Care Providers During COVID 19: A Remote Mindfulness Intervention

TypeinterventionalSponsorStanford UniversityRan2021 to 2022Enrolled52ConditionsAnxiety Depression, BurnoutArmsMindfulness session
NCT04834154 nacompletednot on this mapstarted 2021, after this paper: background citation

Addressing Mental Health Disparities in Spanish Speaking Latina Breast Cancer Patients

TypeinterventionalSponsorStanford UniversityRan2021 to 2022Enrolled31ConditionsBreast Cancer, Depression, Anxiety, Mindfulness, Sleep DisturbanceArmsMindfulness, Control group
NCT06017765 narecruitingnot on this mapstarted 2023, after this paper: background citation

Coping After Loss Through Mindfulness Training in Grieving Adults With Prolonged Grief Disorder - A Neuroimaging Pilot Study

TypeinterventionalSponsorUniversity Hospital, CaenRan2023 to 2026Enrolled30ConditionsProlonged Grief DisorderArmsMeditation Training, Waitlist
3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Resilience Interventions Conducted in Western and Eastern Countries-A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Guideline
  13. Pooled it
  14. Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elizabeth A HogeCenter for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, One Bowdoin Sq, 6th Floor, Boston, MA 02114 ehoge@partners.org.
Eric Bui
Luana Marques
Christina A Metcalf
Laura K Morris
Donald J Robinaugh
John J Worthington
Mark H Pollack
Naomi M Simon

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
IMPLEMENTATION OF COGNITIVE PROCESSING THERAPY FOR PTSD IN DIVERSE COMMUNITIESK23MH096029 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MARQUES, LUANA · 2012 to 2016
$931k
MBSR and Anxiety: Therapeutic and Neuroendocrine EffectsK23AT004432 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI HOGE, ELIZABETH A · 2008 to 2013
$698k
NCCIH NIH HHS K23 AT004432NCRR NIH HHS UL1 RR 025758NCRR NIH HHS UL1 RR025758NIMH NIH HHS K23 MH096029
6 · The paper itself

Abstract

objectiveMindfulness meditation has met increasing interest as a therapeutic strategy for anxiety disorders, but prior studies have been limited by methodological concerns, including a lack of an active comparison group. This is the first randomized, controlled trial comparing the manualized Mindfulness-Based Stress Reduction (MBSR) program with an active control for generalized anxiety disorder (GAD), a disorder characterized by chronic worry and physiologic hyperarousal symptoms.

methodNinety-three individuals with DSM-IV-diagnosed GAD were randomly assigned to an 8-week group intervention with MBSR or to an attention control, Stress Management Education (SME), between 2009 and 2011. Anxiety symptoms were measured with the Hamilton Anxiety Rating Scale (HAMA; primary outcome measure), the Clinical Global Impressions-Severity of Illness and -Improvement scales (CGI-S and CGI-I), and the Beck Anxiety Inventory (BAI). Stress reactivity was assessed by comparing anxiety and distress during pretreatment and posttreatment administration of the Trier Social Stress Test (TSST).

resultsA modified intent-to-treat analysis including participants who completed at least 1 session of MBSR (n = 48) or SME (n = 41) showed that both interventions led to significant (P < .0001) reductions in HAMA scores at endpoint, but did not significantly differ. MBSR, however, was associated with a significantly greater reduction in anxiety as measured by the CGI-S, the CGI-I, and the BAI (all P values < .05). MBSR was also associated with greater reductions than SME in anxiety and distress ratings in response to the TSST stress challenge (P < .05) and a greater increase in positive self-statements (P = .004).

conclusionsThese results suggest that MBSR may have a beneficial effect on anxiety symptoms in GAD and may also improve stress reactivity and coping as measured in a laboratory stress challenge.

trial registrationClinicalTrials.gov identifier: NCT01033851.

Indexed as

ArousalAwarenessAdaptation, PsychologicalAdultAnxiety DisordersCombined Modality TherapyFemaleFollow-Up StudiesHumansInterview, PsychologicalMaleMeditationMiddle AgedPatient Education as TopicProblem SolvingSelf Concept

Identifiers

PMID23541163
PMCPMC3772979

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.