Evidence map›Paper›PMID 23541000›Full record

ReviewBiological psychiatry2013

Stress as a common risk factor for obesity and addiction.

Rajita Sinha, Ania M Jastreboff

Registry-linked trialAbstract readReview
In one paragraph

Review in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05347914 (Mobile Mindfulness Intervention to Reduce Non-Homeostatic Food Cravings in Emotional Eaters), which is not on this map. Cited by 253 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
253citing papers in PubMed, 5 pooled it
43.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05347914 nacompletednot on this mapstarted 2022, after this paper: background citation

Mobile Mindfulness Intervention to Reduce Non-Homeostatic Food Cravings in Emotional Eaters: Research Pilot

TypeinterventionalSponsorMcGill UniversityRan2022 to 2023Enrolled49ConditionsEmotional EatingArmsMindfulness
3 · Its place in the literature

Who cites it

253 citing papers in PubMed, 5 syntheses or guidelines pooled it, 598 citations in OpenAlex.

  1. Pooled it
  2. Effects of total diet replacement programs on mental well-being: A systematic review with meta-analyses.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Pooled it
  3. Cash transfer programs and child health and family economic outcomes: a systematic review.Canadian journal of public health = Revue canadienne de sante publique · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Efficacy and safety of Ashwagandha (Journal of medicine and life · 2025
    Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. The Biochemical Role of Bitter Melon (Food science & nutrition · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Review

193 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rajita SinhaYale Stress Center, Department of Psychiatry, Neurobiology and Child Study, Yale University School of Medicine, New Haven, CT 06519, USA. rajita.sinha@yale.edu
Ania M Jastreboff
Yale University · US

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Interdisciplinary Research on Stress, Self-Control & AddictionUL1DE019586 · NIDCR · YALE UNIVERSITY · PI SINHA, RAJITA · 2008 to 2011
$5.0M
Career Development Programs in Diabetes Research for Pediatrics EndocrinologistsK12DK094714 · NIDDK · YALE UNIVERSITY · PI TAMBORLANE, WILLIAM V · 2011 to 2020
$4.3M
Protocols, Statistics, Collaborative Method Development and ToolsPL1DA024859 · NIDA · YALE UNIVERSITY · PI SINHA, RAJITA · 2007 to 2011
$3.6M
NCRR NIH HHS UL1 RR024139NCRR NIH HHS UL1-RR024139NIDA NIH HHS PL1 DA024859NIDA NIH HHS PL1-DA024859NIDCR NIH HHS UL1 DE019586NIDCR NIH HHS UL1-DE019586NIDDK NIH HHS 1K12DK094714-01NIDDK NIH HHS K12 DK094714
6 · The paper itself

Abstract

Stress is associated with obesity, and the neurobiology of stress overlaps significantly with that of appetite and energy regulation. This review will discuss stress, allostasis, the neurobiology of stress and its overlap with neural regulation of appetite, and energy homeostasis. Stress is a key risk factor in the development of addiction and in addiction relapse. High levels of stress changes eating patterns and augments consumption of highly palatable (HP) foods, which in turn increases incentive salience of HP foods and allostatic load. The neurobiological mechanisms by which stress affects reward pathways to potentiate motivation and consumption of HP foods as well as addictive drugs is discussed. With enhanced incentive salience of HP foods and overconsumption of these foods, there are adaptations in stress and reward circuits that promote stress-related and HP food-related motivation as well as concomitant metabolic adaptations, including alterations in glucose metabolism, insulin sensitivity, and other hormones related to energy homeostasis. These metabolic changes in turn might also affect dopaminergic activity to influence food motivation and intake of HP foods. An integrative heuristic model is proposed, wherein repeated high levels of stress alter the biology of stress and appetite/energy regulation, with both components directly affecting neural mechanisms contributing to stress-induced and food cue-induced HP food motivation and engagement in overeating of such foods to enhance risk of weight gain and obesity. Future directions in research are identified to increase understanding of the mechanisms by which stress might increase risk of weight gain and obesity.

Indexed as

Behavior, AddictiveBrainCuesFeeding BehaviorHumansHyperphagiaMotivationObesityRisk FactorsStress, Psychological

Identifiers

PMID23541000
PMCPMC3658316
OpenAlexW2023326323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.