ArticleJournal of the American Chemical Society2013
Emergence of glass-like behavior in Markov state models of protein folding dynamics.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- The Role of the Electronic Structure during Protein Folding through Electron Density-Based Quantum Chemical Descriptors.ACS omega · 2026Article
- Identical sequences, different behaviors: Protein diversity captured at the single-molecule level.Biophysical journal · 2024Article
- Unsupervised Learning Methods for Molecular Simulation Data.Chemical reviews · 2021Article
- EspcTM: Kinetic Transition Network Based on Trajectory Mapping in Effective Energy Rescaling Space.Frontiers in molecular biosciences · 2020Article
- Equilibrium versus Nonequilibrium Peptide Dynamics: Insights into Transient 2D IR Spectroscopy.The journal of physical chemistry. B · 2018Review
- Rare Dissipative Transitions Punctuate the Initiation of Chemical Denaturation in Proteins.Biophysical journal · 2018Article
- Evaluation of the hybrid resolution PACE model for the study of folding, insertion, and pore formation of membrane associated peptides.Journal of computational chemistry · 2017Article
- Principles and Overview of Sampling Methods for Modeling Macromolecular Structure and Dynamics.PLoS computational biology · 2016Review
- Estimating first-passage time distributions from weighted ensemble simulations and non-Markovian analyses.Protein science : a publication of the Protein Society · 2016Article
- Markov state models provide insights into dynamic modulation of protein function.Accounts of chemical research · 2015Review
- Systematically constructing kinetic transition network in polypeptide from top to down: trajectory mapping.PloS one · 2015Article
- Dynamical phase transitions reveal amyloid-like states on protein folding landscapes.Biophysical journal · 2014Article
- Markov state models of biomolecular conformational dynamics.Current opinion in structural biology · 2014Review
- Comparing protein folding in vitro and in vivo: foldability meets the fitness challenge.Current opinion in structural biology · 2014Review
- Inclusion of persistence length-based secondary structure in replica field theoretic models of heteropolymer freezing.The Journal of chemical physics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The extent to which glass-like kinetics govern dynamics in protein folding has been heavily debated. Here, we address the subject with an application of space-time perturbation theory to the dynamics of protein folding Markov state models. Borrowing techniques from the s-ensemble method, we argue that distinct active and inactive phases exist for protein folding dynamics, and that kinetics for specific systems can fall into either dynamical regime. We do not, however, observe a true glass transition in any system studied. We go on to discuss how these inactive and active phases might relate to general protein folding properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.