Evidence map›Paper›PMID 23540650›Full record

ArticleTrends in immunology2013

Antigen cross-presentation by dendritic cell subsets: one general or all sergeants?

Stefan Nierkens, Jurjen Tel, Edith Janssen, Gosse J Adema

Abstract read
In one paragraph

Article in Trends in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
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  9. Myelin-reactive CD8Journal of neuroinflammation · 2025
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Stefan NierkensNijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Tumor Immunology Laboratory, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands.
Jurjen Tel
Edith Janssen
Gosse J Adema
Radboud University Medical Center · NLCincinnati Children's Hospital Medical Center · USRadboud University Nijmegen · NL

Funding

Activating robust immunity to tumor-associated antigens:mechanisms and biologyR01CA138617 · NCI · CINCINNATI CHILDRENS HOSP MED CTR · PI JANSSEN, EDITH M · 2009 to 2013
$1.5M
Dendritic Cells in the Breaking of Peripheral Tolerance in Type 1 DiabetesR01DK090978 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI JANSSEN, EDITH M, KATZ, JONATHAN DAVID · 2010 to 2012
$843k
NCI NIH HHS R01 CA138617NIDDK NIH HHS R01 DK090978
6 · The paper itself

Abstract

Antigen cross-presentation describes the process through which dendritic cells (DCs) acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross-present has been thought of as a feature of specialized DC subsets. Emerging data, however, suggest that the cross-presenting ability of each DC subset is tuned by and dependent on several factors, such as DC location and activation status, and the type of antigen and inflammatory signals. Thus, we argue that capacity of cross-presentation is not an exclusive trait of one or several distinct DC subtypes, but rather a common feature of the DC family in both mice and humans. Understanding DC subset activation and antigen-presentation pathways might yield improved tools and targets to exploit the unique cross-presenting capacity of DCs in immunotherapy.

Indexed as

AnimalsAntigen PresentationAntigen-Presenting CellsCross-PrimingDendritic CellsHumansantigen presentationcross-presentationdendritic cell subsetsimmunotherapy

Identifiers

PMID23540650
PMCPMC4351710
OpenAlexW2038784764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.