ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2013
Influence of chronic comorbidity and medication on the efficacy of treatment in patients with diabetes in general practice.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 0 citations in OpenAlex.
- Efficacy and safety of canagliflozin in patients with type 2 diabetes based on history of cardiovascular disease or cardiovascular risk factors: a post hoc analysis of pooled data.Cardiovascular diabetology · 2017Trial
- The effect of mHealth program on behavior modification and health outcomes among patients with diabetes: A randomized controlled trial study.Belitung nursing journal · 2023Article
- Effective Overall Glycaemic Control with Fast-Acting Insulin Aspart Across Patients with Different Baseline Characteristics: A Post Hoc Analysis of the Onset 9 Trial.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022Article
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- A Metabolomics Approach to Pharmacotherapy Personalization.Journal of personalized medicine · 2018Review
- Clinical drug trials in general practice: how well are external validity issues reported?BMC family practice · 2017Review
- Economic burden of comorbidities in psoriasis patients in the United States: results from a retrospective U.S. database.BMC health services research · 2017Article
- Role of Tiotropium in Reducing Exacerbations of Chronic Obstructive Pulmonary Disease When Combined With Long-Acting βJournal of clinical pharmacology · 2016Observational
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence on the influence of comorbidity and comedication on clinical outcomes in patients with type 2 diabetes mellitus is scarce.
aimTo ascertain the effect of five chronic diseases (joint disorder, respiratory disease, anaemia, malignancy, depression) and three chronically used drugs (non-steroid anti-inflammatory drugs [NSAIDs], corticosteroids, antidepressants) on treatment for hypoglycaemia in patients with type 2 diabetes. DESIGN AND
settingRetrospective cohort study in a variety of practices across Flanders, Belgium.
methodA retrospective cohort study was conducted, based on data from Intego, a general practice-based continuous morbidity registry. Multiple logistic regression analysis was used to predict the change in glycosylated haemoglobin (HbA1c) levels related to comorbidity, comedication, and a combination of both in 3416 patients with type 2 diabetes. Adjustments were made for age, sex, and diabetes-treatment group (diet, oral antidiabetic drugs, combination treatment, insulin).
resultsConcomitant joint and respiratory disorders, as well as the chronic use of NSAIDs and corticosteroids, either separately or in combination, were significantly associated with the worsening of HbA1c levels. Anaemia, depression, malignancy, and antidepressants had no statistically significant influence on the efficacy of treatment for hypoglycaemia.
conclusionThe presence of some comorbid diseases or drug use can impede the efficacy of treatment for type 2 diabetes. This finding supports the need to develop treatment recommendations, taking into account the presence of both chronic comorbidity and comedication. Further research must be undertaken to ascertain the effect other combinations of chronic diseases have on the efficacy of treatment of this and other diseases.
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