Biochemistry. A protease for the ages.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed.

1. Prelamin A and ZMPSTE24 in premature and physiological aging.Nucleus (Austin, Tex.) · 2023
   Review
2. Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation.Cell death & disease · 2023
   Article
3. The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation.mBio · 2022
   Article
4. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells.eLife · 2021
   Article
5. Targeting RAS-converting enzyme 1 overcomes senescence and improves progeria-like phenotypes of ZMPSTE24 deficiency.Aging cell · 2020
   Article
6. Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.PloS one · 2020
   Article
7. A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24.Methods (San Diego, Calif.) · 2019
   Review
8. Membrane properties that shape the evolution of membrane enzymes.Current opinion in structural biology · 2018
   Review
9. Permanently Farnesylated Prelamin A, Progeria, and Atherosclerosis.Circulation · 2018
   Article
10. Disease models & mechanisms · 2018
    Article
11. Autophagic Removal of Farnesylated Carboxy-Terminal Lamin Peptides.Cells · 2018
    Article
12. The Protease Ste24 Clears Clogged Translocons.Cell · 2016
    Article
13. New ZMPSTE24 (FACE1) mutations in patients affected with restrictive dermopathy or related progeroid syndromes and mutation update.European journal of human genetics : EJHG · 2014
    Article
14. Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24.The Journal of biological chemistry
    Article

Corrections and comments

• Comment on
  Structure of the integral membrane protein CAAX protease Ste24p.2013
• Comment on
  The structural basis of ZMPSTE24-dependent laminopathies.2013

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as