Evidence map›Paper›PMID 23539500›Full record

ArticleFuture neurology2012

Persistent region-dependent neuroinflammation, NMDA receptor loss and atrophy in an animal model of penetrating brain injury.

Rachel Grossman, Charles M Paden, Pamela A Fry, Ryon Sun Rhodes, Anat Biegon

Abstract read
In one paragraph

Article in Future neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  3. Article
  4. Review
  5. Review
  6. [Molecules (Basel, Switzerland) · 2018
    Article
  7. Microglial Activation in Traumatic Brain Injury.Frontiers in aging neuroscience · 2017
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Rachel GrossmanNeurosurgery Department, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Charles M Paden
Pamela A Fry
Ryon Sun Rhodes
Anat Biegon
Montana State University · USBrookhaven National Laboratory · USSheba Medical Center · IL

Funding

NMDA Receptor Dynamics After Brain InjuryR01NS050285 · NINDS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI BIEGON, ANAT · 2007 to 2011
$1.8M
NINDS NIH HHS R01 NS050285
6 · The paper itself

Abstract

Dynamic changes in neuroinflammation and glutamate NMDA receptors (NMDAR) have been noted in traumatic and ischemic brain injury.

aimHere we investigate the time course and regional distribution of these changes and their relationship with atrophy in a rat model of penetrating brain injury. MATERIALS

methodsQuantitative autoradiography, with the neuroinflammation marker [

resultsThe injury produced large increases in [

conclusionThese results indicate that neuroinflammaton and loss of NMDAR precede and predict tissue atrophy in cortical and hippocampal regions.

Indexed as

brain atrophybrain injuryneuroinflammationNMDA receptorsperipheral benzodiazepine receptorsTSPO

Identifiers

PMID23539500
PMCPMC3607550
OpenAlexW2129373396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.