SynthesisCurrent psychiatry reports2013
Antipsychotic and psychostimulant drug combination therapy in attention deficit/hyperactivity and disruptive behavior disorders: a systematic review of efficacy and tolerability.
Synthesis in Current psychiatry reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Long-acting injectable antipsychotics for early psychosis: A comprehensive systematic review.PloS one · 2022Pooled it
- Antipsychotic treatment patterns and cardiometabolic medicine use: current real-world evidence.Epidemiology and psychiatric sciences · 2026Article
- Psychotropic Polypharmacy and Related Factors in Children and Adolescents.Psychiatry investigation · 2025Article
- Movement disorders and use of risperidone and methylphenidate: a review of case reports and an analysis of the WHO database in pharmacovigilance.European child & adolescent psychiatry · 2021Review
- A Focused Review of the Metabolic Side-Effects of Clozapine.Frontiers in endocrinology · 2021Review
- Inter-class Concomitant Pharmacotherapy in Medicaid-Insured Youth Receiving Psychiatric Residential Treatment.Frontiers in psychiatry · 2021Article
- Duration of Neurocognitive Impairment With Medical Cannabis Use: A Scoping Review.Frontiers in psychiatry · 2021Article
- A comparison of the metabolic side-effects of the second-generation antipsychotic drugs risperidone and paliperidone in animal models.PloS one · 2021Article
- Suicidal and non-suicidal self-injurious behaviour in patients with bipolar disorder and comorbid attention deficit hyperactivity disorder after initiation of central stimulant treatment: a mirror-image study based on the LiSIE retrospective cohort.Therapeutic advances in psychopharmacology · 2020Article
- Differential Effects of Acute Treatment With Antipsychotic Drugs on Peripheral Catecholamines.Frontiers in psychiatry · 2020Article
- Psychotropic Polypharmacy Among Children and Youth Receiving Medicaid, 2012-2015.Journal of managed care & specialty pharmacy · 2018Article
- Long-Term Metabolic Effects in French-Canadian Children and Adolescents Treated with Second-Generation Antipsychotics in Monotherapy or Polytherapy: A 24-Month Descriptive Retrospective Study.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Article
- Outpatient antipsychotic drug use in children and adolescents in Germany between 2004 and 2011.European child & adolescent psychiatry · 2017Article
- Low-dose quetiapine complements stimulant response in attention deficit hyperactivity disorder and more.Therapeutic advances in psychopharmacology · 2016Article
- Behavioral Weight Loss Treatment in Antipsychotic Treated Youth.Scandinavian journal of child and adolescent psychiatry and psychology · 2016Article
- Adiposity and Cardiometabolic Risk in Children With and Without Antipsychotic Drug Treatment.The Journal of clinical endocrinology and metabolism · 2015Article
- Combined stimulant and antipsychotic treatment in adolescents with attention-deficit/hyperactivity disorder: a cross-sectional observational structural MRI study.European child & adolescent psychiatry · 2015Observational
- Predictors of concomitant use of antipsychotics and stimulants and its impact on stimulant persistence in pediatric attention deficit hyperactivity disorder.Journal of managed care & specialty pharmacy · 2015Article
- DSM-5: disruptive mood dysregulation disorder.Asian journal of psychiatry · 2014Review
- Managing ADHD and disruptive behaviour disorders with combination psychostimulant and antipsychotic treatment.Journal of psychiatry & neuroscience : JPN · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This systematic review examines treatment guidelines, efficacy/effectiveness, and tolerability regarding the use of antipsychotics concurrently with psychostimulants in treating aggression and hyperactivity in children and adolescents. Articles examining the concurrent use of antipsychotics and psychostimulants to treat comorbid attention deficit/hyperactivity disorder (ADHD) and disruptive behavior disorders (DBDs) were identified and their results were summarized and critically analyzed. Antipsychotic and stimulant combination therapy is recommended by some guidelines, but only as a third-line treatment following stimulant monotherapy and stimulants combined with behavioral interventions to treat aggression in patients with ADHD. Some studies suggest efficacy/effectiveness for an antipsychotic and stimulant combination in the treatment of aggression and hyperactivity in children and adolescents. However, the data do not clearly demonstrate superiority compared to antipsychotic or psychostimulant monotherapy. Most studies were performed over short time periods, several lacked blinding, few studies used any placebo control, and no comparisons were made with behavioral interventions. There are concerns about the tolerability of combination therapy, but data do not suggest significantly worse adverse effects for combination compared to either antipsychotic or stimulant monotherapy. Conversely, and contrary to speculation, use of a stimulant does not significantly reduce metabolic effects of antipsychotics. Combination treatment with antipsychotics and psychostimulants is used frequently, and increasingly more often. Few studies have directly examined this combination for the treatment of ADHD and DBDs. Further studies are necessary to confirm the efficacy and tolerability of the concurrent use of antipsychotics and psychostimulants in children and adolescents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.