ArticleeLife2013
LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Rho signaling promotes cell excitability and synaptic transmission.bioRxiv : the preprint server for biology · 2025Article
- TheThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Muscle-directed mechanosensory feedback activates egg-laying circuit activity and behavior in Caenorhabditis elegans.Current biology : CB · 2023Article
- Article
- SALSA, a genetically encoded biosensor for spatiotemporal quantification of Notch signal transduction in vivo.Developmental cell · 2022Article
- Article
- Post-Developmental Roles of Notch Signaling in the Nervous System.Biomolecules · 2020Review
- Dynamic Regulation of Adult-Specific Functions of the Nervous System by Signaling from the Reproductive System.Current biology : CB · 2019Article
- The HSN egg-laying command neurons regulate the defecation motor program inmicroPublication biology · 2019Article
- Serotonin and neuropeptides are both released by the HSN command neuron to initiate Caenorhabditis elegans egg laying.PLoS genetics · 2019Article
- LIN-12/Notch Regulates GABA Signaling at theG3 (Bethesda, Md.) · 2018Article
- Homeostatic Feedback Modulates the Development of Two-State Patterned Activity in a Model Serotonin Motor Circuit inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The DSL ligand APX-1 is required for normal ovulation in C. elegans.Developmental biology · 2018Article
- Ratiometric Calcium Imaging of Individual Neurons in Behaving Caenorhabditis Elegans.Journal of visualized experiments : JoVE · 2018Article
- Non-neuronal cell outgrowth inWorm · 2017Review
- Activity of theeLife · 2016Article
- HES-Mediated Repression of Pten in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2015Article
- A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. elegans.Developmental biology · 2014Article
- Growth factors in synaptic function.Frontiers in synaptic neuroscience · 2013Review
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4 authors at 2 institutions in 1 country.
Funding
Abstract
The diverse cell types and the precise synaptic connectivity between them are the cardinal features of the nervous system. Little is known about how cell fate diversification is linked to synaptic target choices. Here we investigate how presynaptic neurons select one type of muscles, vm2, as a synaptic target and form synapses on its dendritic spine-like muscle arms. We found that the Notch-Delta pathway was required to distinguish target from non-target muscles. APX-1/Delta acts in surrounding cells including the non-target vm1 to activate LIN-12/Notch in the target vm2. LIN-12 functions cell-autonomously to up-regulate the expression of UNC-40/DCC and MADD-2 in vm2, which in turn function together to promote muscle arm formation and guidance. Ectopic expression of UNC-40/DCC in non-target vm1 muscle is sufficient to induce muscle arm extension from these cells. Therefore, the LIN-12/Notch signaling specifies target selection by selectively up-regulating guidance molecules and forming muscle arms in target cells. DOI:http://dx.doi.org/10.7554/eLife.00378.001.
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