ReviewWiley interdisciplinary reviews. Developmental biology
The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles.
Review in Wiley interdisciplinary reviews. Developmental biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 107 citations in OpenAlex.
- Pathogen subversion of neuro-epidermal signaling impairs lysosomal function to disrupt collagen homeostasis in Caenorhabditis elegans.PLoS biology · 2026Article
- Novel Insights into the Pleiotropic Neuroprotective Action of Synthetic Halogen Free Thyronamine-like Analogues.Molecules (Basel, Switzerland) · 2026Article
- LIN-24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin-Like Protein in C. elegans.Journal of applied toxicology : JAT · 2026Review
- MYRF drives heterochronic miRNAs and LIN-42, and amplifies oscillatory programs for stage transitions.bioRxiv : the preprint server for biology · 2026Article
- Benzo[a]pyrene-Induced Developmental Toxicity inToxics · 2025Article
- Article
- The neuron-intrinsic membrane skeleton is required for motor neuron integrity throughout lifespan.bioRxiv : the preprint server for biology · 2025Article
- Validation of metaxin-2 deficient C. elegans as a model for MandibuloAcral Dysplasia associated to mtx-2 (MADaM) syndrome.Communications biology · 2024Article
- Structural and physiological functions ofHeliyon · 2024Review
- Dynein directs prophase centrosome migration to control the stem cell division axis in the developing Caenorhabditis elegans epidermis.Genetics · 2024Article
- Introduction toJournal of nematology · 2024Article
- Enhanced biodegradable polyester film degradation in soil by sequential cooperation of yeast-derived esterase and microbial community.Environmental science and pollution research international · 2024Article
- In vivo efficacy of silver nanoparticles againstJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023Article
- ACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans.Nature communications · 2023Article
- Signaling circuits and the apical extracellular matrix in aging: connections identified in the nematodeAmerican journal of physiology. Cell physiology · 2023Review
- Article
- A member of the CAP protein superfamily, Hc-CAP-15, is important for the parasitic-stage development of Haemonchus contortus.Parasites & vectors · 2023Article
- Triggered Golgi membrane enrichment promotes PtdIns(4,5)P2 generation for plasma membrane repair.The Journal of cell biology · 2023Article
- Emerging roles of mitochondria in animal regeneration.Cell regeneration (London, England) · 2023Review
- Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Caenorhabditis elegans epidermis forms one of the principal barrier epithelia of the animal. Differentiation of the epidermis begins in mid embryogenesis and involves apical-basal polarization of the cytoskeletal and secretory systems as well as cellular junction formation. Secretion of the external cuticle layers is one of the major developmental and physiological specializations of the epidermal epithelium. The four post-embryonic larval stages are separated by periodic moults, in which the epidermis generates a new cuticle with stage-specific characteristics. The differentiated epidermis also plays key roles in endocrine signaling, fat storage, and ionic homeostasis. The epidermis is intimately associated with the development and function of the nervous system, and may have glial-like roles in modulating neuronal function. The epidermis provides passive and active defenses against skin-penetrating pathogens and can repair small wounds. Finally, age-dependent deterioration of the epidermis is a prominent feature of aging and may affect organismal aging and lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.