ArticleLipids2013
Liver fatty acid binding protein gene-ablation exacerbates weight gain in high-fat fed female mice.
Article in Lipids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- The effects ofIranian journal of basic medical sciences · 2023Review
- Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2018Article
- Loss of fatty acid binding protein-1 alters the hepatic endocannabinoid system response to a high-fat diet.Journal of lipid research · 2017Article
- Silencing of FABP1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease.FEBS open bio · 2017Article
- Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver?Nutrition & metabolism · 2017Article
- Fabp1 gene ablation inhibits high-fat diet-induced increase in brain endocannabinoids.Journal of neurochemistry · 2017Article
- Article
- Female Mice are Resistant to Fabp1 Gene Ablation-Induced Alterations in Brain Endocannabinoid Levels.Lipids · 2016Article
- Recent insights into the biological functions of liver fatty acid binding protein 1.Journal of lipid research · 2015Review
- Phenotypic divergence in two lines of L-Fabp-/- mice reflects substrain differences and environmental modifiers.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Association of L-FABP T94A and MTP I128T polymorphisms with hyperlipidemia in Chinese subjects.Lipids · 2015Article
- Enterocyte fatty acid-binding proteins (FABPs): different functions of liver and intestinal FABPs in the intestine.Prostaglandins, leukotrienes, and essential fatty acids · 2015Review
- Icariin is a PPARα activator inducing lipid metabolic gene expression in mice.Molecules (Basel, Switzerland) · 2014Article
- Organic anion uptake by hepatocytes.Comprehensive Physiology · 2014Review
- Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-α activation in cultured human female hepatocytes.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism.Journal of lipid research · 2014Article
- Direct comparison of mice null for liver or intestinal fatty acid-binding proteins reveals highly divergent phenotypic responses to high fat feeding.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Loss of liver fatty acid binding protein (L-FABP) decreases long chain fatty acid uptake and oxidation in primary hepatocytes and in vivo. On this basis, L-FABP gene ablation would potentiate high-fat diet-induced weight gain and weight gain/energy intake. While this was indeed the case when L-FABP null (-/-) mice on the C57BL/6NCr background were pair-fed a high-fat diet, whether this would also be observed under high-fat diet fed ad libitum was not known. Therefore, this possibility was examined in female L-FABP (-/-) mice on the same background. L-FABP (-/-) mice consumed equal amounts of defined high-fat or isocaloric control diets fed ad libitum. However, on the ad libitum-fed high-fat diet the L-FABP (-/-) mice exhibited: (1) decreased hepatic long chain fatty acid (LCFA) β-oxidation as indicated by lower serum β-hydroxybutyrate level; (2) decreased hepatic protein levels of key enzymes mitochondrial (rate limiting carnitine palmitoyl acyltransferase A1, CPT1A; HMG-CoA synthase) and peroxisomal (acyl CoA oxidase 1, ACOX1) LCFA β-oxidation; (3) increased fat tissue mass (FTM) and FTM/energy intake to the greatest extent; and (4) exacerbated body weight gain, weight gain/energy intake, liver weight, and liver weight/body weight to the greatest extent. Taken together, these findings showed that L-FABP gene-ablation exacerbated diet-induced weight gain and fat tissue mass gain in mice fed high-fat diet ad libitum--consistent with the known biochemistry and cell biology of L-FABP.
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