Evidence map›Paper›PMID 23539318›Full record

ReviewJournal of applied physiology (Bethesda, Md. : 1985)2013

Effects of prostaglandins and COX-inhibiting drugs on skeletal muscle adaptations to exercise.

Todd A Trappe, Sophia Z Liu

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 95 citations in OpenAlex.

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  8. COX Inhibitor Influence on Skeletal Muscle Fiber Size and Metabolic Adaptations to Resistance Exercise in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016
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  9. Effects of dietary Docosahexaenoic, training and acute exercise on lipid mediators.Journal of the International Society of Sports Nutrition · 2016
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Todd A TrappeHuman Performance Laboratory, Ball State University, Muncie, Indiana.
Sophia Z Liu
Ball State University · US

Funding

Analgesics and resistance training in older individualsR01AG020532 · NIA · UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK · PI TRAPPE, TODD A · 2004 to 2008
$1.4M
NIA NIH HHS AG-00831NIA NIH HHS AG-020532
6 · The paper itself

Abstract

It has been ∼40 yr since the discovery that PGs are produced by exercising skeletal muscle and since the discovery that inhibition of PG synthesis is the mechanism of action of what are now known as cyclooxygenase (COX)-inhibiting drugs. Since that time, it has been established that PGs are made during and after aerobic and resistance exercise and have a potent paracrine and autocrine effect on muscle metabolism. Consequently, it has also been determined that orally consumed doses of COX inhibitors can profoundly influence muscle PG synthesis, muscle protein metabolism, and numerous other cellular processes that regulate muscle adaptations to exercise loading. Although data from acute human exercise studies, as well as animal and cell-culture data, would predict that regular consumption of a COX inhibitor during exercise training would dampen the typical muscle adaptations, the chronic data do not support this conjecture. From the studies in young and older individuals, lasting from 1.5 to 4 mo, no interfering effects of COX inhibitors on muscle adaptations to resistance-exercise training have been noted. In fact, in older individuals, a substantial enhancement of muscle mass and strength has been observed. The collective findings of the PG/COX-pathway regulation of skeletal muscle responses and adaptations to exercise are compelling. Considering the discoveries in other areas of COX regulation of health and disease, there is certainly an interesting future of investigation in this re-emerging area, especially as it pertains to older individuals and the condition of sarcopenia, as well as exercise training and performance of individuals of all ages.

Indexed as

Adaptation, PhysiologicalAnimalsCyclooxygenase InhibitorsExerciseHumansMuscle, SkeletalProstaglandin-Endoperoxide SynthasesProstaglandinsSignal TransductionCyclooxygenase InhibitorsProstaglandin-Endoperoxide SynthasesProstaglandinsacetaminophenibuprofenPGE2PGF2αsarcopenia

Identifiers

PMID23539318
PMCPMC3764617
OpenAlexW2019843440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.