ArticleSensors and actuators. B, Chemical2011
A microfluidic platform for electrical detection of DNA hybridization.
Article in Sensors and actuators. B, Chemical, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- High Sensitivity Extended Nano-Coulter Counter for Detection of Viral Particles and Extracellular Vesicles.Analytical chemistry · 2023Article
- A Review on Microfluidics-Based Impedance Biosensors.Biosensors · 2023Review
- A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis.Biosensors · 2021Review
- Ultrasensitive detection of cadmium ions using a microcantilever-based piezoresistive sensor for groundwater.Beilstein journal of nanotechnology · 2020Article
- Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations.Molecules (Basel, Switzerland) · 2019Review
- Fully integrated wearable impedance cytometry platform on flexible circuit board with online smartphone readout.Microsystems & nanoengineering · 2018Article
- Microfluidic and Nanofluidic Resistive Pulse Sensing: A Review.Micromachines · 2017Review
- Portable Cytometry Using Microscale Electronic Sensing.Sensors and actuators. B, Chemical · 2016Article
- Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering.Sensors (Basel, Switzerland) · 2015Review
- Single Cell Electrical Characterization Techniques.International journal of molecular sciences · 2015Review
- Multiplexed actuation using ultra dielectrophoresis for proteomics applications: a comprehensive electrical and electrothermal design methodology.Lab on a chip · 2014Article
- New tools and new biology: recent miniaturized systems for molecular and cellular biology.Molecules and cells · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Current methods used for detection of DNA hybridization involve the use of DNA microarrays which require overnight incubation times along with bulky and expensive fluorescent scanners. Here, we demonstrate electrical detection of DNA hybridization in an oligonucleotide functionalized microfluidic channel. We use microchannels functionalized with DNA probes integrated with electrodes for measuring conductance across the channel. As beads conjugated with the target DNA passing through the channel are captured on the surface, we are able to electrically detect changes in resistance due to bead capture. Our assay can be completed in less than an hour using less than a microliter of reagent, and has the potential for extensive multiplexing. Such a device can be useful as a handheld platform in a clinical setting where one would need to rapidly genotype a small number of genes rapidly.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.