ArticleAdvanced synthesis & catalysis2012
Exploiting Acyl and Enol Azolium Intermediates via NHeterocyclic Carbene Catalyzed Reactions of Alpha-Reducible Aldehydes.
Article in Advanced synthesis & catalysis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 389 citations in OpenAlex.
- Review
- Nickel-Catalyzed Cross-Dehydrogenative Allylation of Aldehydes.Journal of the American Chemical Society · 2026Article
- Carbon and Heteroatom Activation via N-Heterocyclic Carbene-Bound Dearomative Intermediates for Stereoselective Annulation Reactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- N-heterocyclic carbene-catalyzed atroposelective synthesis of N-Aryl phthalimides and maleimides via activation of carboxylic acids.Nature communications · 2024Article
- α-Phenylthioaldehydes for the effective generation of acyl azolium and azolium enolate intermediates.Chemical science · 2024Article
- Redox Active N-Heterocyclic Carbenes in Oxidative NHC Catalysis.Organic letters · 2024Article
- Asymmetric Synthesis of α-Chloroamides via Photoenzymatic Hydroalkylation of Olefins.Journal of the American Chemical Society · 2024Article
- Direct allylic acylation via cross-coupling involving cooperative N‑heterocyclic carbene, hydrogen atom transfer, and photoredox catalysis.Nature communications · 2023Article
- Site-Selective, Photocatalytic Vinylogous Amidation of Enones.Organic letters · 2022Article
- Catalyst-Controlled Selectivity Switch in Three-Component Reaction: An NHC-Catalyzed Strategy for the Synthesis of δ-Lactone-Fused Spirobenzofuran-3-ones.Molecules (Basel, Switzerland) · 2022Article
- First example of organocatalysis by cathodic N-heterocyclic carbene generation and accumulation using a divided electrochemical flow cell.Beilstein journal of organic chemistry · 2022Article
- N-Heterocyclic Carbene/Carboxylic Acid Co-Catalysis Enables Oxidative Esterification of Demanding Aldehydes/Enals, at Low Catalyst Loading.Angewandte Chemie (International ed. in English) · 2021Article
- NHC-catalyzed covalent activation of heteroatoms for enantioselective reactions.Chemical science · 2021Review
- Acyl Donor Intermediates in N-Heterocyclic Carbene Catalysis: Acyl Azolium or Azolium Enolate?Angewandte Chemie (International ed. in English) · 2021Article
- Chemo-selective cross reaction of two enalsChemical science · 2020Article
- Organocatalytic Name Reactions Enabled by NHCs.Materials (Basel, Switzerland) · 2020Review
- Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids.Angewandte Chemie (International ed. in English) · 2020Article
- Article
- New Developments of the Principle of Vinylogy as Applied to π-Extended Enolate-Type Donor Systems.Chemical reviews · 2020Article
- N-Heterocyclic Carbene Catalyzed Photoenolization/Diels-Alder Reaction of Acid Fluorides.Angewandte Chemie (International ed. in English) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
N-heterocyclic carbenes are well known for their role in catalyzing benzoin and Stetter reactions: the generation of acyl anion equivalents from simple aldehydes to react with a variety of electrophiles. However, when an aldehyde bearing a leaving group or unsaturation adjacent to the acyl anion equivalent is subjected to an NHC, a new avenue of reactivity is unlocked, leading to a number of novel transformations which can generate highly complex products from simple starting materials, many of which are assembled through unconventional bond disconnections. The field of these new reactions - those utilizing
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.