ArticlePrimary care respiratory journal : journal of the General Practice Airways Group2013
Using the DOSE index to predict changes in health status of patients with COPD: a prospective cohort study.
Article in Primary care respiratory journal : journal of the General Practice Airways Group, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02882165 (A Quantitative Study in Early Chronic Obstructive Pulmonary Disease, Using a Cluster Analysis, to Establish if Prospective, Individualised, Medical Intervention Alters Projected Clinical Course), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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A Quantitative Study in Early Chronic Obstructive Pulmonary Disease, Using a Cluster Analysis, to Establish if Prospective, Individualised, Medical Intervention Alters Projected Clinical Course
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic models for outcome prediction in patients with chronic obstructive pulmonary disease: systematic review and critical appraisal.BMJ (Clinical research ed.) · 2019Pooled it
- Development and validation of a novel AI-derived index for predicting COPD medical costs in clinical practice.Computational and structural biotechnology journal · 2025Article
- The DOSE index in chronic obstructive pulmonary disease: evaluating healthcare costs.BMC pulmonary medicine · 2024Article
- CONQUEST Quality Standards: For the Collaboration on Quality Improvement Initiative for Achieving Excellence in Standards of COPD Care.International journal of chronic obstructive pulmonary disease · 2021Article
- Primary care risk stratification in COPD using routinely collected data: a secondary data analysis.NPJ primary care respiratory medicine · 2019Article
- Associations between chronic comorbidity and exacerbation risk in primary care patients with COPD.Respiratory research · 2017Article
- External validation of multidimensional prognostic indices (ADO, BODEx and DOSE) in a primary care international cohort (PROEPOC/COPD cohort).BMC pulmonary medicine · 2016Observational
- Change in health status in COPD: a seven-year follow-up cohort study.NPJ primary care respiratory medicine · 2016Article
- Multi-component assessment of chronic obstructive pulmonary disease: an evaluation of the ADO and DOSE indices and the global obstructive lung disease categories in international primary care data sets.NPJ primary care respiratory medicine · 2016Observational
- Improving communication between the physician and the COPD patient: an evaluation of the utility of the COPD Assessment Test in primary care.Patient related outcome measures · 2014Review
- Assessment of COPD in primary care: new evidence supports use of the DOSE index.Primary care respiratory journal : journal of the General Practice Airways Group · 2013Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe severity of chronic obstructive pulmonary disease (COPD) should not be based on the level of airflow limitation alone. A multicomponent index such as the DOSE index (dyspnoea score (D), level of airflow obstruction (O), current smoking status (S), and exacerbations (E)) has the potential to predict important future outcomes in patients with COPD more effectively than the forced expiratory volume in one second. Health status deterioration should be prevented in COPD patients.
aimsTo investigate whether the DOSE index can predict which patients are at risk of a clinically relevant change in health status.
methodsA prospective cohort study was performed using data from primary and secondary care. The DOSE score was determined at baseline and the 2-year change in the Clinical COPD Questionnaire (CCQ) score was calculated. Linear regression analysis was performed for the effect of a high DOSE score (≥ 4) on the change in CCQ score.
resultsThe study population consisted of 209 patients (112 patients from primary care). Overall, a high DOSE score was a significant predictor of a change in CCQ score after 2 years (0.41, 95% CI 0.13 to 0.70), particularly in primary care patients.
conclusionsA DOSE score of ≥ 4 has the ability to identify COPD patients with a greater risk of future worsening in health status.
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