ArticleRetina (Philadelphia, Pa.)2013
Plus disease diagnosis in retinopathy of prematurity: vascular tortuosity as a function of distance from optic disk.
Article in Retina (Philadelphia, Pa.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Automatic Diagnosis of Plus Disease in Retinopathy of Prematurity Using Deep Learning.Beyoglu eye journal · 2026Article
- Establishing an objective quantitative method for assessing the severity of plus disease in retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Automated diagnosis of plus disease in retinopathy of prematurity using quantification of vessels characteristics.Scientific reports · 2024Article
- Accuracy and Reliability of Eye-Based vs Quadrant-Based Diagnosis of Plus Disease in Retinopathy of Prematurity.JAMA ophthalmology · 2018Article
- Retinopathy of Prematurity-assist: Novel Software for Detecting Plus Disease.Korean journal of ophthalmology : KJO · 2017Article
- Posterior Pole Vascular Changes Before Treatment of Retinopathy of Prematurity.JAMA ophthalmology · 2017Article
- Plus Disease in Retinopathy of Prematurity: Diagnostic Trends in 2016 Versus 2007.American journal of ophthalmology · 2017Article
- Plus Disease in Retinopathy of Prematurity: A Continuous Spectrum of Vascular Abnormality as a Basis of Diagnostic Variability.Ophthalmology · 2016Article
- Plus Disease in Retinopathy of Prematurity: Improving Diagnosis by Ranking Disease Severity and Using Quantitative Image Analysis.Ophthalmology · 2016Article
- Computer-aided diagnosis of retinopathy in retinal fundus images of preterm infants via quantification of vascular tortuosity.Journal of medical imaging (Bellingham, Wash.) · 2016Article
- Diagnostic Discrepancies in Retinopathy of Prematurity Classification.Ophthalmology · 2016Observational
- Expert Diagnosis of Plus Disease in Retinopathy of Prematurity From Computer-Based Image Analysis.JAMA ophthalmology · 2016Article
- Comprehensive Retinal Image Analysis for Aggressive Posterior Retinopathy of Prematurity.PloS one · 2016Article
- Computer-Based Image Analysis for Plus Disease Diagnosis in Retinopathy of Prematurity: Performance of the "i-ROP" System and Image Features Associated With Expert Diagnosis.Translational vision science & technology · 2015Article
- Plus Disease in Retinopathy of Prematurity: More Than Meets the ICROP?Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Review
- Automated Quantitative Assessment of Retinal Vascular Tortuosity in Patients with Sickle Cell Disease.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo examine vascular tortuosity as a function of distance from the optic disk in infants with retinopathy of prematurity.
methodsThirty-four wide-angle retinal images from infants with retinopathy of prematurity were reviewed by 22 experts. A reference standard for each image was defined as the diagnosis (plus vs. not plus) given by the majority of experts. Tortuosity, defined as vessel length divided by straight line distance between vessel end points, was calculated as a function of distance from the disk margin for arteries and veins using computer-based methods developed by the authors.
resultsMean cumulative tortuosity increased with distance from the disk margin, both in 13 images with plus disease (P = 0.007 for arterial tortuosity [n = 62 arteries], P < 0.001 for venous tortuosity [n = 58 veins] based on slope of best fit line by regression), and in 21 images without plus disease (P < 0.001 for arterial tortuosity [n = 94 arteries], P <0 .001 for venous tortuosity [n = 85 veins]). Images with plus disease had significantly higher vascular tortuosity than images without plus disease (P < 0.05), up to 7.0 disk diameters from the optic disk margin.
conclusionVascular tortuosity was higher peripherally than centrally, both in images with and without plus disease, suggesting that peripheral retinal features may be relevant for retinopathy of prematurity diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.