Evidence map›Paper›PMID 23538558›Full record

ArticleCellular logistics2012

Search for inhibitors of endocytosis: Intended specificity and unintended consequences.

Dipannita Dutta, Julie G Donaldson

Abstract read
In one paragraph

Article in Cellular logistics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 205 papers.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

205 citing papers in PubMed.

  1. Article
  2. Protein-enhanced small molecule disruptors of ordered membrane domains.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Pharmaceutics · 2026
    Article
  6. Article
  7. Review
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  20. Article

145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dipannita DuttaCell Biology & Physiology Center; National Heart, Lung, and Blood Institute; National Institutes of Health; Bethesda, MD USA.
Julie G Donaldson

Funding

Mechanisms of Clathrin-Independent EndocytosisZIAHL006130 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DONALDSON, JULIE G · 2011 to 2018
$5.8M
6 · The paper itself

Abstract

We discuss here the variety of approaches that have been taken to inhibit different forms of endocytosis. Typically, both non-specific and specific chemical inhibitors of endocytosis are tried in order to "classify" entry of a new plasma membrane protein into one of the various types of endocytosis. This classification can be confirmed through genetic approaches of protein depletion or overexpression of mutants of known endocytosis machinery components. Although some new compounds have been designed to be selective in biochemical assays, we caution investigators to be alert to the unintended consequences that sometimes arise when these compounds are applied to intact cells.

Indexed as

chemical inhibitorclathrin-independent endocytosisclathrin-mediated endocytosisendocytosisinhibitorphagocytosispinocytosis

Identifiers

PMID23538558
PMCPMC3607622

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.