Evidence map›Paper›PMID 23538551›Full record

ArticleJournal of ocular biology, diseases, and informatics2011

Eyes on DNA methylation: current evidence for DNA methylation in ocular development and disease.

Deborah C Otteson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ocular biology, diseases, and informatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Deborah C OttesonDepartment of Basic and Vision Sciences, College of Optometry, University of Houston, 4901 Calhoun Rd, Rm 2195, Houston, TX 77204-2020 USA ; Department of Biology and Biochemistry, College of Natural Sciences and Mathematics, University of Houston, Houston, TX 77204-2020 USA.
University of Houston · US

Funding

Regulation of Ephrin Receptor Expression in the RetinaR01EY021792 · NEI · UNIVERSITY OF HOUSTON · PI OTTESON, DEBORAH C · 2011 to 2015
$1.6M
NEI NIH HHS R01 EY021792
6 · The paper itself

Abstract

Epigenetic modulation of chromatin states constitutes a vital component of the cellular repertoire of transcriptional regulatory mechanisms. The development of new technologies capable of generating genome-wide maps of chromatin modifications has re-energized the field. We are now poised to determine how species- and tissue-specific patterns of DNA methylation, in concert with other chromatin modifications, function to establish and maintain cell- and tissue-specific patterns of gene expression during normal development, cellular differentiation, and disease. This review addresses our current understanding of the major mechanisms and function of DNA methylation in vertebrates with a historical perspective and an emphasis on what is known about DNA methylation in eye development and disease.

Indexed as

DNA methylationLensMüller gliaOcular cancerRetinaTranscriptional regulation

Identifiers

PMID23538551
PMCPMC3382291
OpenAlexW2044452407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.