Evidence map›Paper›PMID 23538490›Full record

ArticleACS medicinal chemistry letters2013

Crown Ether Host-Rotaxanes as Cytotoxic Agents.

David B Smithrud, Xiaoyang Wang, Pheruza Tarapore, Shuk-Mei Ho

Open access · greenAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Molecular Machines For The Control Of Transmembrane Transport.Journal of the American Chemical Society · 2023
    Review
  3. CaACS medicinal chemistry letters · 2017
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

David B SmithrudDepartment of Chemistry, University of Cincinnati, Cincinnati, Ohio 452212.
Xiaoyang Wang
Pheruza Tarapore
Shuk-Mei Ho
University of Cincinnati · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer RiskU01ES019480 · NIEHS · UNIVERSITY OF CINCINNATI · PI HO, SHUK-MEI · 2010 to 2014
$2.2M
Chronic exposure to Biphenol A and uterine cancer risk markersU01ES020988 · NIEHS · UNIVERSITY OF CINCINNATI · PI HO, SHUK-MEI · 2011 to 2014
$796k
Smart, enzyme-activated MRI contrast agents for cancer detectionR21EB012122 · NIBIB · UNIVERSITY OF CINCINNATI · PI SMITHRUD, DAVID B · 2012 to 2013
$379k
G-protein coupled receptor-30(GPR30):a putative new therapeutic target for PCaI01BX000675 · VA · CINCINNATI VA MEDICAL CENTER RESEARCH · PI HO, SHUK-MEI · 2011 to 2019
–
BLRD VA I01 BX000675NCATS NIH HHS UL1 TR001425NIBIB NIH HHS R21 EB012122NIEHS NIH HHS P30 ES006096NIEHS NIH HHS U01 ES019480NIEHS NIH HHS U01 ES020988
6 · The paper itself

Abstract

Highly toxic bacterial ionophores are commonly used in veterinary medicine, but their therapeutic index is too narrow for human usage. With the goal of developing ionophores with a broader therapeutic index, we constructed highly derivatized synthetic ionophores. The toxicities of crown ether host-rotaxanes (CEHR's) against the SKOV-3 cell line were measured. The effect of Mg

Indexed as

ApoptosisCalciumCrown EthersMagnesiumRotaxanes

Identifiers

PMID23538490
PMCPMC3607455
OpenAlexW2023282273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.