Evidence map›Paper›PMID 23538404›Full record

ReviewResearch in microbiology

The Sec-dependent pathway.

Jon Beckwith

Abstract readReview
In one paragraph

Review in Research in microbiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Biomolecules · 2026
    Article
  2. Review
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  5. Review
  6. Article
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  10. Article
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  12. Cells · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Biological Features and In Planta Transcriptomic Analyses of aInternational journal of molecular sciences · 2022
    Article
  17. Article
  18. How Do Biomolecules Cross the Cell Membrane?Accounts of chemical research · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jon BeckwithDepartment of Microbiology and Immunobiology, Harvard Medical School, HIM Building, Room 1047,77 Avenue Louis Pasteur, Boston, MA 02115, USA. jbeckwith@hms.harvard.edu

Funding

Microbial Diversity in Mechanisms of Disulfide Bond Formation and ReductionR01GM041883 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BOYD, DANA · 1989 to 2014
$7.8M
NIGMS NIH HHS R01 GM041883
6 · The paper itself

Abstract

The Sec pathway for export of proteins across the cytoplasmic membrane to the bacterial periplasm and outer membrane was the first secretion pathway to be discovered in bacteria. A combination of bacterial genetics, development of an in vitro membrane vesicle system and the concurrent elaboration of the signal hypothesis from studies on eukaryotes led to the identification and characterization of two pathways leading to protein export through the SecYEG cytoplasmic membrane translocon. The Sec pathway is also required for assembly of proteins into the cytoplasmic membrane. Since the membrane translocon for Sec pathways is conserved across the three domains of life, the history of research progress in eukaryotes and bacteria was facilitated by the close interaction between those studying both classes of organisms.

Indexed as

Bacterial Secretion SystemsBacteriaBacterial ProteinsCell MembraneProtein TransportBacterial ProteinsBacterial Secretion SystemsCo-translational secretionGene fusionsPost-translational secretionSecYEGSRP

Identifiers

PMID23538404
PMCPMC3706482

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.