ArticleBehavioural brain research2013
Repeated restraint stress enhances cue-elicited conditioned freezing and impairs acquisition of extinction in an age-dependent manner.
Article in Behavioural brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Estrous cycle stage gates the effect of stress on reward learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice.Frontiers in molecular neuroscience · 2023Article
- Structural, functional, and behavioral significance of sex and gonadal hormones in the basolateral amygdala: A review of preclinical literature.Alcohol (Fayetteville, N.Y.) · 2022Review
- Environmental certainty influences the neural systems regulating responses to threat and stress.Neuroscience and biobehavioral reviews · 2021Review
- Paradoxical changes in mood-related behaviors on continuous social isolation after weaning.Experimental brain research · 2021Article
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- Prefrontal α7nAChR Signaling Differentially Modulates Afferent Drive and Trace Fear Conditioning Behavior in Adolescent and Adult Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Downregulation of parvalbumin expression in the prefrontal cortex during adolescence causes enduring prefrontal disinhibition in adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- MK-801 Exposure during Adolescence Elicits Enduring Disruption of Prefrontal E-I Balance and Its Control of Fear Extinction Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Fear Learning Enhances Prefrontal Cortical Suppression of Auditory Thalamic Inputs to the Amygdala in Adults, but Not Adolescents.International journal of molecular sciences · 2020Article
- Overexpression of TIPE2, a Negative Regulator of Innate and Adaptive Immunity, Attenuates Cognitive Deficits in APP/PS1 Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019Article
- Disruptive effects of repeated stress on basolateral amygdala neurons and fear behavior across the estrous cycle in rats.Scientific reports · 2019Article
- Maturational Changes in Prefrontal and Amygdala Circuits in Adolescence: Implications for Understanding Fear Inhibition during a Vulnerable Period of Development.Brain sciences · 2019Review
- Persistent pain intensifies recall of consolidated fear memories.Neurobiology of stress · 2019Article
- Social modulation of fear: Facilitation vs buffering.Genes, brain, and behavior · 2019Review
- Article
- Susceptibility and Resilience to Posttraumatic Stress Disorder-like Behaviors in Inbred Mice.Biological psychiatry · 2017Article
- Sex- and Estrus-Dependent Differences in Rat Basolateral Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Differential effects of stress on fear learning and activation of the amygdala in pre-adolescent and adult male rats.Neuroscience · 2017Article
- Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Affective disorders are believed to involve dysfunction within the amygdala, a key structure for processing emotional information. Chronic stress may contribute to affective disorders such as depression and anxiety via its effects on the amygdala. Previous research has shown that chronic stress increases amygdala neuronal activity in an age-dependent manner. However, whether these distinct changes in amgydala neuronal activity are accompanied by age-dependent changes in amygdala-dependent affective behavior is unclear. In this study, we investigated how chronic stress impacts amgydala-dependent auditory fear conditioning in adolescent and adult rats in a repeated restraint model. We found that repeated restraint enhanced conditioned freezing in both adolescent and adult rats. But repeated restraint led to impaired acquisition of fear extinction only in adolescent rats. Along with previous findings, these results suggest that chronic stress may precipitate affective disorders via differential mechanisms, with different outcomes at different ages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.